Signs of innate immune activation and premature immunosenescence in psoriasis patients

Abstract Psoriasis is a chronic inflammatory disease that affects skin and is associated with systemic inflammation and many serious comorbidities ranging from metabolic syndrome to cancer. Important discoveries about psoriasis pathogenesis have enabled the development of effective biological treatm...

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Autores principales:	Liisi Šahmatova, Elena Sügis, Marina Šunina, Helen Hermann, Ele Prans, Maire Pihlap, Kristi Abram, Ana Rebane, Hedi Peterson, Pärt Peterson, Külli Kingo, Kai Kisand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4b1b57406ed42e5929a1e737febdd9e
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spelling	oai:doaj.org-article:a4b1b57406ed42e5929a1e737febdd9e2021-12-02T12:32:58ZSigns of innate immune activation and premature immunosenescence in psoriasis patients10.1038/s41598-017-07975-22045-2322https://doaj.org/article/a4b1b57406ed42e5929a1e737febdd9e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07975-2https://doaj.org/toc/2045-2322Abstract Psoriasis is a chronic inflammatory disease that affects skin and is associated with systemic inflammation and many serious comorbidities ranging from metabolic syndrome to cancer. Important discoveries about psoriasis pathogenesis have enabled the development of effective biological treatments blocking the T helper 17 pathway. However, it has not been settled whether psoriasis is a T cell-mediated autoimmune disease or an autoinflammatory disorder that is driven by exaggerated innate immune signalling. Our comparative gene expression and hierarchical cluster analysis reveal important gene circuits involving innate receptors. Innate immune activation is indicated by increased absent in melanoma 2 (AIM2) inflammasome gene expression and active caspase 1 staining in psoriatic lesional skin. Increased eomesodermin (EOMES) expression in lesional and non-lesional skin is suggestive of innate-like virtual memory CD8+ T cell infiltration. We found that signs of systemic inflammation were present in most of the patients, correlated with the severity of the disease, and pointed to IL-6 involvement in the pathogenesis of psoriatic arthritis. Among the circulating T cell subpopulations, we identified a higher proportion of terminally differentiated or senescent CD8+ T cells, especially in patients with long disease duration, suggesting premature immunosenescence and its possible implications for psoriasis co-morbidities.Liisi ŠahmatovaElena SügisMarina ŠuninaHelen HermannEle PransMaire PihlapKristi AbramAna RebaneHedi PetersonPärt PetersonKülli KingoKai KisandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liisi Šahmatova Elena Sügis Marina Šunina Helen Hermann Ele Prans Maire Pihlap Kristi Abram Ana Rebane Hedi Peterson Pärt Peterson Külli Kingo Kai Kisand Signs of innate immune activation and premature immunosenescence in psoriasis patients
description	Abstract Psoriasis is a chronic inflammatory disease that affects skin and is associated with systemic inflammation and many serious comorbidities ranging from metabolic syndrome to cancer. Important discoveries about psoriasis pathogenesis have enabled the development of effective biological treatments blocking the T helper 17 pathway. However, it has not been settled whether psoriasis is a T cell-mediated autoimmune disease or an autoinflammatory disorder that is driven by exaggerated innate immune signalling. Our comparative gene expression and hierarchical cluster analysis reveal important gene circuits involving innate receptors. Innate immune activation is indicated by increased absent in melanoma 2 (AIM2) inflammasome gene expression and active caspase 1 staining in psoriatic lesional skin. Increased eomesodermin (EOMES) expression in lesional and non-lesional skin is suggestive of innate-like virtual memory CD8+ T cell infiltration. We found that signs of systemic inflammation were present in most of the patients, correlated with the severity of the disease, and pointed to IL-6 involvement in the pathogenesis of psoriatic arthritis. Among the circulating T cell subpopulations, we identified a higher proportion of terminally differentiated or senescent CD8+ T cells, especially in patients with long disease duration, suggesting premature immunosenescence and its possible implications for psoriasis co-morbidities.
format	article
author	Liisi Šahmatova Elena Sügis Marina Šunina Helen Hermann Ele Prans Maire Pihlap Kristi Abram Ana Rebane Hedi Peterson Pärt Peterson Külli Kingo Kai Kisand
author_facet	Liisi Šahmatova Elena Sügis Marina Šunina Helen Hermann Ele Prans Maire Pihlap Kristi Abram Ana Rebane Hedi Peterson Pärt Peterson Külli Kingo Kai Kisand
author_sort	Liisi Šahmatova
title	Signs of innate immune activation and premature immunosenescence in psoriasis patients
title_short	Signs of innate immune activation and premature immunosenescence in psoriasis patients
title_full	Signs of innate immune activation and premature immunosenescence in psoriasis patients
title_fullStr	Signs of innate immune activation and premature immunosenescence in psoriasis patients
title_full_unstemmed	Signs of innate immune activation and premature immunosenescence in psoriasis patients
title_sort	signs of innate immune activation and premature immunosenescence in psoriasis patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a4b1b57406ed42e5929a1e737febdd9e
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Signs of innate immune activation and premature immunosenescence in psoriasis patients

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