MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION

Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparat...

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Autores principales:	S. G. Gamaley, A. V. Bateneva, Z. F. Urmantseva, G. M. Sisoyeva, Ya. V. Markus, E. D. Danilenko, V. K. Mikhaylova, E. A. Volosnikova, G. M. Levagina, V. I. Masicheva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	tumor necrosis factor alpha tnf-α rheopolyglukin polyethylene glycol Science Q
Acceso en línea:	https://doaj.org/article/a4b553a9be424c77aef48066059e5cb1
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id	oai:doaj.org-article:a4b553a9be424c77aef48066059e5cb1
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spelling	oai:doaj.org-article:a4b553a9be424c77aef48066059e5cb12021-11-23T06:14:19ZMEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION2541-94202587-9596https://doaj.org/article/a4b553a9be424c77aef48066059e5cb12012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/931https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparation TNF-α+PG+PEG provided a moderately prolonged elevation of TNF-alpha in blood of laboratory mice in contrast to TNF-α when they applied to the skin. The composite preparation did not have toxic, allergic and locally irritating action in experiments on laboratory animals.S. G. GamaleyA. V. BatenevaZ. F. UrmantsevaG. M. SisoyevaYa. V. MarkusE. D. DanilenkoV. K. MikhaylovaE. A. VolosnikovaG. M. LevaginaV. I. MasichevaScientific Сentre for Family Health and Human Reproduction Problemsarticletumor necrosis factor alphatnf-αrheopolyglukinpolyethylene glycolScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 264-266 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	tumor necrosis factor alpha tnf-α rheopolyglukin polyethylene glycol Science Q
spellingShingle	tumor necrosis factor alpha tnf-α rheopolyglukin polyethylene glycol Science Q S. G. Gamaley A. V. Bateneva Z. F. Urmantseva G. M. Sisoyeva Ya. V. Markus E. D. Danilenko V. K. Mikhaylova E. A. Volosnikova G. M. Levagina V. I. Masicheva MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION
description	Composite preparation of tumor necrosis factor alpha and rheopolyglukin and polyethylene glycol (TNF-α+PG+PEG) was obtained. The specific activity of the samples was 4,13 х 107 IU/mg. The cytolytic activity of drugs TNF-α+PG+PEG and rhTNF-α did not change after 4 months when stored at 6 °С. Preparation TNF-α+PG+PEG provided a moderately prolonged elevation of TNF-alpha in blood of laboratory mice in contrast to TNF-α when they applied to the skin. The composite preparation did not have toxic, allergic and locally irritating action in experiments on laboratory animals.
format	article
author	S. G. Gamaley A. V. Bateneva Z. F. Urmantseva G. M. Sisoyeva Ya. V. Markus E. D. Danilenko V. K. Mikhaylova E. A. Volosnikova G. M. Levagina V. I. Masicheva
author_facet	S. G. Gamaley A. V. Bateneva Z. F. Urmantseva G. M. Sisoyeva Ya. V. Markus E. D. Danilenko V. K. Mikhaylova E. A. Volosnikova G. M. Levagina V. I. Masicheva
author_sort	S. G. Gamaley
title	MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION
title_short	MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION
title_full	MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION
title_fullStr	MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION
title_full_unstemmed	MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION
title_sort	medicinal form of tnf-α for local administration
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/a4b553a9be424c77aef48066059e5cb1
work_keys_str_mv	AT sggamaley medicinalformoftnfaforlocaladministration AT avbateneva medicinalformoftnfaforlocaladministration AT zfurmantseva medicinalformoftnfaforlocaladministration AT gmsisoyeva medicinalformoftnfaforlocaladministration AT yavmarkus medicinalformoftnfaforlocaladministration AT eddanilenko medicinalformoftnfaforlocaladministration AT vkmikhaylova medicinalformoftnfaforlocaladministration AT eavolosnikova medicinalformoftnfaforlocaladministration AT gmlevagina medicinalformoftnfaforlocaladministration AT vimasicheva medicinalformoftnfaforlocaladministration
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MEDICINAL FORM OF TNF-α FOR LOCAL ADMINISTRATION

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