Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation
Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by phosphatidylserine during myotube formation.
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Nature Portfolio
2018
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oai:doaj.org-article:a4b94536489a4c5abfb6db09652f94982021-12-02T14:40:08ZCell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation10.1038/s41467-018-04436-w2041-1723https://doaj.org/article/a4b94536489a4c5abfb6db09652f94982018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04436-whttps://doaj.org/toc/2041-1723Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by phosphatidylserine during myotube formation.Masaki TsuchiyaYuji HaraMasaki OkudaKarin ItohRyotaro NishiokaAkifumi ShiomiKohjiro NagaoMasayuki MoriYasuo MoriJunichi IkenouchiRyo SuzukiMotomu TanakaTomohiko OhwadaJunken AokiMotoi KanagawaTatsushi TodaYosuke NagataRyoichi MatsudaYasunori TakayamaMakoto TominagaMasato UmedaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Masaki Tsuchiya Yuji Hara Masaki Okuda Karin Itoh Ryotaro Nishioka Akifumi Shiomi Kohjiro Nagao Masayuki Mori Yasuo Mori Junichi Ikenouchi Ryo Suzuki Motomu Tanaka Tomohiko Ohwada Junken Aoki Motoi Kanagawa Tatsushi Toda Yosuke Nagata Ryoichi Matsuda Yasunori Takayama Makoto Tominaga Masato Umeda Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation |
| description |
Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by phosphatidylserine during myotube formation. |
| format |
article |
| author |
Masaki Tsuchiya Yuji Hara Masaki Okuda Karin Itoh Ryotaro Nishioka Akifumi Shiomi Kohjiro Nagao Masayuki Mori Yasuo Mori Junichi Ikenouchi Ryo Suzuki Motomu Tanaka Tomohiko Ohwada Junken Aoki Motoi Kanagawa Tatsushi Toda Yosuke Nagata Ryoichi Matsuda Yasunori Takayama Makoto Tominaga Masato Umeda |
| author_facet |
Masaki Tsuchiya Yuji Hara Masaki Okuda Karin Itoh Ryotaro Nishioka Akifumi Shiomi Kohjiro Nagao Masayuki Mori Yasuo Mori Junichi Ikenouchi Ryo Suzuki Motomu Tanaka Tomohiko Ohwada Junken Aoki Motoi Kanagawa Tatsushi Toda Yosuke Nagata Ryoichi Matsuda Yasunori Takayama Makoto Tominaga Masato Umeda |
| author_sort |
Masaki Tsuchiya |
| title |
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation |
| title_short |
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation |
| title_full |
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation |
| title_fullStr |
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation |
| title_full_unstemmed |
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation |
| title_sort |
cell surface flip-flop of phosphatidylserine is critical for piezo1-mediated myotube formation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/a4b94536489a4c5abfb6db09652f9498 |
| work_keys_str_mv |
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| _version_ |
1718390435052781568 |