GSTA4 mediates reduction of cisplatin ototoxicity in female mice

A common complication of cisplatin-based chemotherapy is hearing loss. Here, Park et al. show that glutathione transferase α4 (GSTA4) contributes to reducing cisplatin toxicity in the inner ear of female mice by removing 4-hydroxynonenal (4-HNE).

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Autores principales:	Hyo-Jin Park, Mi-Jung Kim, Christina Rothenberger, Ashok Kumar, Edith M. Sampson, Dalian Ding, Chul Han, Karessa White, Kevin Boyd, Senthilvelan Manohar, Yong-Hwan Kim, Maria S. Ticsa, Aaron S. Gomez, Isabela Caicedo, Upal Bose, Paul J. Linser, Takuya Miyakawa, Masaru Tanokura, Thomas C. Foster, Richard Salvi, Shinichi Someya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4b9d8b940ff4c42bbb2c14bdd319a1a
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spelling	oai:doaj.org-article:a4b9d8b940ff4c42bbb2c14bdd319a1a2021-12-02T15:36:05ZGSTA4 mediates reduction of cisplatin ototoxicity in female mice10.1038/s41467-019-12073-02041-1723https://doaj.org/article/a4b9d8b940ff4c42bbb2c14bdd319a1a2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12073-0https://doaj.org/toc/2041-1723A common complication of cisplatin-based chemotherapy is hearing loss. Here, Park et al. show that glutathione transferase α4 (GSTA4) contributes to reducing cisplatin toxicity in the inner ear of female mice by removing 4-hydroxynonenal (4-HNE).Hyo-Jin ParkMi-Jung KimChristina RothenbergerAshok KumarEdith M. SampsonDalian DingChul HanKaressa WhiteKevin BoydSenthilvelan ManoharYong-Hwan KimMaria S. TicsaAaron S. GomezIsabela CaicedoUpal BosePaul J. LinserTakuya MiyakawaMasaru TanokuraThomas C. FosterRichard SalviShinichi SomeyaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyo-Jin Park Mi-Jung Kim Christina Rothenberger Ashok Kumar Edith M. Sampson Dalian Ding Chul Han Karessa White Kevin Boyd Senthilvelan Manohar Yong-Hwan Kim Maria S. Ticsa Aaron S. Gomez Isabela Caicedo Upal Bose Paul J. Linser Takuya Miyakawa Masaru Tanokura Thomas C. Foster Richard Salvi Shinichi Someya GSTA4 mediates reduction of cisplatin ototoxicity in female mice
description	A common complication of cisplatin-based chemotherapy is hearing loss. Here, Park et al. show that glutathione transferase α4 (GSTA4) contributes to reducing cisplatin toxicity in the inner ear of female mice by removing 4-hydroxynonenal (4-HNE).
format	article
author	Hyo-Jin Park Mi-Jung Kim Christina Rothenberger Ashok Kumar Edith M. Sampson Dalian Ding Chul Han Karessa White Kevin Boyd Senthilvelan Manohar Yong-Hwan Kim Maria S. Ticsa Aaron S. Gomez Isabela Caicedo Upal Bose Paul J. Linser Takuya Miyakawa Masaru Tanokura Thomas C. Foster Richard Salvi Shinichi Someya
author_facet	Hyo-Jin Park Mi-Jung Kim Christina Rothenberger Ashok Kumar Edith M. Sampson Dalian Ding Chul Han Karessa White Kevin Boyd Senthilvelan Manohar Yong-Hwan Kim Maria S. Ticsa Aaron S. Gomez Isabela Caicedo Upal Bose Paul J. Linser Takuya Miyakawa Masaru Tanokura Thomas C. Foster Richard Salvi Shinichi Someya
author_sort	Hyo-Jin Park
title	GSTA4 mediates reduction of cisplatin ototoxicity in female mice
title_short	GSTA4 mediates reduction of cisplatin ototoxicity in female mice
title_full	GSTA4 mediates reduction of cisplatin ototoxicity in female mice
title_fullStr	GSTA4 mediates reduction of cisplatin ototoxicity in female mice
title_full_unstemmed	GSTA4 mediates reduction of cisplatin ototoxicity in female mice
title_sort	gsta4 mediates reduction of cisplatin ototoxicity in female mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a4b9d8b940ff4c42bbb2c14bdd319a1a
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GSTA4 mediates reduction of cisplatin ototoxicity in female mice

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