Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations

Although combination antiretroviral (ARV) therapy is highly effective in controlling the progression of HIV disease, drug resistance can be a major obstacle. Recent findings suggest that resistance can develop without ARV target gene mutations.

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Auteurs principaux:	Yuta Hikichi, Rachel Van Duyne, Phuong Pham, Jennifer L. Groebner, Ann Wiegand, John W. Mellors, Mary F. Kearney, Eric O. Freed
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2021
Sujets:	Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/a4bd72fa01324caca28f6cbce9932f14
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spelling	oai:doaj.org-article:a4bd72fa01324caca28f6cbce9932f142021-11-03T18:15:37ZMechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations2161-21292150-751110.1128/mBio.03134-20https://doaj.org/article/a4bd72fa01324caca28f6cbce9932f142021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03134-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 Although combination antiretroviral (ARV) therapy is highly effective in controlling the progression of HIV disease, drug resistance can be a major obstacle. Recent findings suggest that resistance can develop without ARV target gene mutations.Yuta HikichiRachel Van DuynePhuong PhamJennifer L. GroebnerAnn WiegandJohn W. MellorsMary F. KearneyEric O. FreedAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Yuta Hikichi Rachel Van Duyne Phuong Pham Jennifer L. Groebner Ann Wiegand John W. Mellors Mary F. Kearney Eric O. Freed Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
description	Although combination antiretroviral (ARV) therapy is highly effective in controlling the progression of HIV disease, drug resistance can be a major obstacle. Recent findings suggest that resistance can develop without ARV target gene mutations.
format	article
author	Yuta Hikichi Rachel Van Duyne Phuong Pham Jennifer L. Groebner Ann Wiegand John W. Mellors Mary F. Kearney Eric O. Freed
author_facet	Yuta Hikichi Rachel Van Duyne Phuong Pham Jennifer L. Groebner Ann Wiegand John W. Mellors Mary F. Kearney Eric O. Freed
author_sort	Yuta Hikichi
title	Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
title_short	Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
title_full	Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
title_fullStr	Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
title_full_unstemmed	Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
title_sort	mechanistic analysis of the broad antiretroviral resistance conferred by hiv-1 envelope glycoprotein mutations
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/a4bd72fa01324caca28f6cbce9932f14
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Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations

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