Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases

Cardiac transcription factors orchestrate a regulatory network controlling cardiovascular development. Isl1, a LIM-homeodomain transcription factor, acts as a key player in multiple organs during embryonic development. Its crucial roles in cardiovascular development have been elucidated by extensive...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jie Ren, Danxiu Miao, Yanshu Li, Rui Gao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Isl1 cardiac transcription factor cardiovascular development second heart field progenitors embryonic development Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a4c07407c1124c4ebb07b5e197f71b14
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a4c07407c1124c4ebb07b5e197f71b14
record_format	dspace
spelling	oai:doaj.org-article:a4c07407c1124c4ebb07b5e197f71b142021-12-01T01:31:37ZSpotlight on Isl1: A Key Player in Cardiovascular Development and Diseases2296-634X10.3389/fcell.2021.793605https://doaj.org/article/a4c07407c1124c4ebb07b5e197f71b142021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.793605/fullhttps://doaj.org/toc/2296-634XCardiac transcription factors orchestrate a regulatory network controlling cardiovascular development. Isl1, a LIM-homeodomain transcription factor, acts as a key player in multiple organs during embryonic development. Its crucial roles in cardiovascular development have been elucidated by extensive studies, especially as a marker gene for the second heart field progenitors. Here, we summarize the roles of Isl1 in cardiovascular development and function, and outline its cellular and molecular modes of action, thus providing insights for the molecular basis of cardiovascular diseases.Jie RenDanxiu MiaoDanxiu MiaoYanshu LiRui GaoFrontiers Media S.A.articleIsl1cardiac transcription factorcardiovascular developmentsecond heart field progenitorsembryonic developmentBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Isl1 cardiac transcription factor cardiovascular development second heart field progenitors embryonic development Biology (General) QH301-705.5
spellingShingle	Isl1 cardiac transcription factor cardiovascular development second heart field progenitors embryonic development Biology (General) QH301-705.5 Jie Ren Danxiu Miao Danxiu Miao Yanshu Li Rui Gao Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
description	Cardiac transcription factors orchestrate a regulatory network controlling cardiovascular development. Isl1, a LIM-homeodomain transcription factor, acts as a key player in multiple organs during embryonic development. Its crucial roles in cardiovascular development have been elucidated by extensive studies, especially as a marker gene for the second heart field progenitors. Here, we summarize the roles of Isl1 in cardiovascular development and function, and outline its cellular and molecular modes of action, thus providing insights for the molecular basis of cardiovascular diseases.
format	article
author	Jie Ren Danxiu Miao Danxiu Miao Yanshu Li Rui Gao
author_facet	Jie Ren Danxiu Miao Danxiu Miao Yanshu Li Rui Gao
author_sort	Jie Ren
title	Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_short	Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_full	Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_fullStr	Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_full_unstemmed	Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_sort	spotlight on isl1: a key player in cardiovascular development and diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a4c07407c1124c4ebb07b5e197f71b14
work_keys_str_mv	AT jieren spotlightonisl1akeyplayerincardiovasculardevelopmentanddiseases AT danxiumiao spotlightonisl1akeyplayerincardiovasculardevelopmentanddiseases AT danxiumiao spotlightonisl1akeyplayerincardiovasculardevelopmentanddiseases AT yanshuli spotlightonisl1akeyplayerincardiovasculardevelopmentanddiseases AT ruigao spotlightonisl1akeyplayerincardiovasculardevelopmentanddiseases
_version_	1718405979642527744

Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases

Ejemplares similares