BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

BRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response that is potentiated by PARP inhibitor treatments.

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Autores principales:	Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londoño-Vallejo, Madalena Tarsounas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4c12a795f2a4463a4d0d639093cc868
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spelling	oai:doaj.org-article:a4c12a795f2a4463a4d0d639093cc8682021-12-02T15:35:06ZBRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors10.1038/s41467-019-11048-52041-1723https://doaj.org/article/a4c12a795f2a4463a4d0d639093cc8682019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11048-5https://doaj.org/toc/2041-1723BRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response that is potentiated by PARP inhibitor treatments.Timo ReisländerEmilia Puig LombardiFlorian J. GroellyAna MiarManuela PorruSerena Di VitoBenjamin WrightHelen LockstoneAnnamaria BiroccioAdrian HarrisArturo Londoño-VallejoMadalena TarsounasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Timo Reisländer Emilia Puig Lombardi Florian J. Groelly Ana Miar Manuela Porru Serena Di Vito Benjamin Wright Helen Lockstone Annamaria Biroccio Adrian Harris Arturo Londoño-Vallejo Madalena Tarsounas BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors
description	BRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response that is potentiated by PARP inhibitor treatments.
format	article
author	Timo Reisländer Emilia Puig Lombardi Florian J. Groelly Ana Miar Manuela Porru Serena Di Vito Benjamin Wright Helen Lockstone Annamaria Biroccio Adrian Harris Arturo Londoño-Vallejo Madalena Tarsounas
author_facet	Timo Reisländer Emilia Puig Lombardi Florian J. Groelly Ana Miar Manuela Porru Serena Di Vito Benjamin Wright Helen Lockstone Annamaria Biroccio Adrian Harris Arturo Londoño-Vallejo Madalena Tarsounas
author_sort	Timo Reisländer
title	BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors
title_short	BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors
title_full	BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors
title_fullStr	BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors
title_full_unstemmed	BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors
title_sort	brca2 abrogation triggers innate immune responses potentiated by treatment with parp inhibitors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a4c12a795f2a4463a4d0d639093cc868
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_version_	1718386674413600768

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

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