Metabolic signals in sleep regulation: recent insights

Charu Shukla, Radhika Basheer Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, West Roxbury, MA, USA Abstract: Sleep and energy balance are essential for health. The two processes act in concert to regulate central and peripheral homeostasis. During sleep, energy is co...

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Autores principales:	Shukla C, Basheer R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Sleep energy balance hypothalamus metabolism homeostasis Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/a4c48df97865452e96494b324efb9804
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spelling	oai:doaj.org-article:a4c48df97865452e96494b324efb98042021-12-02T00:22:04ZMetabolic signals in sleep regulation: recent insights1179-1608https://doaj.org/article/a4c48df97865452e96494b324efb98042016-01-01T00:00:00Zhttps://www.dovepress.com/metabolic-signals-in-sleep-regulation-recent-insights-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Charu Shukla, Radhika Basheer Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, West Roxbury, MA, USA Abstract: Sleep and energy balance are essential for health. The two processes act in concert to regulate central and peripheral homeostasis. During sleep, energy is conserved due to suspended activity, movement, and sensory responses, and is redirected to restore and replenish proteins and their assemblies into cellular structures. During wakefulness, various energy-demanding activities lead to hunger. Thus, hunger promotes arousal, and subsequent feeding, followed by satiety that promotes sleep via changes in neuroendocrine or neuropeptide signals. These signals overlap with circuits of sleep-wakefulness, feeding, and energy expenditure. Here, we will briefly review the literature that describes the interplay between the circadian system, sleep-wake, and feeding-fasting cycles that are needed to maintain energy balance and a healthy metabolic profile. In doing so, we describe the neuroendocrine, hormonal/peptide signals that integrate sleep and feeding behavior with energy metabolism. Keywords: sleep, energy balance, hypothalamus, metabolism, homeostasisShukla CBasheer RDove Medical PressarticleSleepenergy balancehypothalamusmetabolismhomeostasisPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2016, Iss Issue 1, Pp 9-20 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sleep energy balance hypothalamus metabolism homeostasis Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Sleep energy balance hypothalamus metabolism homeostasis Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Shukla C Basheer R Metabolic signals in sleep regulation: recent insights
description	Charu Shukla, Radhika Basheer Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, West Roxbury, MA, USA Abstract: Sleep and energy balance are essential for health. The two processes act in concert to regulate central and peripheral homeostasis. During sleep, energy is conserved due to suspended activity, movement, and sensory responses, and is redirected to restore and replenish proteins and their assemblies into cellular structures. During wakefulness, various energy-demanding activities lead to hunger. Thus, hunger promotes arousal, and subsequent feeding, followed by satiety that promotes sleep via changes in neuroendocrine or neuropeptide signals. These signals overlap with circuits of sleep-wakefulness, feeding, and energy expenditure. Here, we will briefly review the literature that describes the interplay between the circadian system, sleep-wake, and feeding-fasting cycles that are needed to maintain energy balance and a healthy metabolic profile. In doing so, we describe the neuroendocrine, hormonal/peptide signals that integrate sleep and feeding behavior with energy metabolism. Keywords: sleep, energy balance, hypothalamus, metabolism, homeostasis
format	article
author	Shukla C Basheer R
author_facet	Shukla C Basheer R
author_sort	Shukla C
title	Metabolic signals in sleep regulation: recent insights
title_short	Metabolic signals in sleep regulation: recent insights
title_full	Metabolic signals in sleep regulation: recent insights
title_fullStr	Metabolic signals in sleep regulation: recent insights
title_full_unstemmed	Metabolic signals in sleep regulation: recent insights
title_sort	metabolic signals in sleep regulation: recent insights
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a4c48df97865452e96494b324efb9804
work_keys_str_mv	AT shuklac metabolicsignalsinsleepregulationrecentinsights AT basheerr metabolicsignalsinsleepregulationrecentinsights
_version_	1718403820144295936

Metabolic signals in sleep regulation: recent insights

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