Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?

<h4>Objectives</h4>To compare blood alkalosis, gastrointestinal symptoms and indicators of strong ion difference after ingestion of 500 mg.kg-1 BM sodium citrate over four different periods.<h4>Methods</h4>Sixteen healthy and active participants ingested 500 mg.kg-1 BM sodium...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Charles S Urwin, Rodney J Snow, Liliana Orellana, Dominique Condo, Glenn D Wadley, Amelia J Carr
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4c7e9e0a9ff40d5a380fe1d395cbdba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a4c7e9e0a9ff40d5a380fe1d395cbdba
record_format	dspace
spelling	oai:doaj.org-article:a4c7e9e0a9ff40d5a380fe1d395cbdba2021-11-25T06:19:12ZDoes varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?1932-620310.1371/journal.pone.0251808https://doaj.org/article/a4c7e9e0a9ff40d5a380fe1d395cbdba2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251808https://doaj.org/toc/1932-6203<h4>Objectives</h4>To compare blood alkalosis, gastrointestinal symptoms and indicators of strong ion difference after ingestion of 500 mg.kg-1 BM sodium citrate over four different periods.<h4>Methods</h4>Sixteen healthy and active participants ingested 500 mg.kg-1 BM sodium citrate in gelatine capsules over a 15, 30, 45 or 60 min period using a randomized cross-over experimental design. Gastrointestinal symptoms questionnaires and venous blood samples were collected before ingestion, immediately post-ingestion, and every 30 min for 480 min post-ingestion. Blood samples were analysed for blood pH, [HCO3-], [Na+], [Cl-] and plasma [citrate]. Linear mixed models were used to estimate the effect of the ingestion protocols.<h4>Results</h4>For all treatments, blood [HCO3-] was significantly elevated above baseline for the entire 480 min post-ingestion period, and peak occurred 180 min post-ingestion. Blood [HCO3-] and pH were significantly elevated above baseline and not significantly below the peak between 150-270 min post-ingestion. Furthermore, blood pH and [HCO3-] were significantly lower for the 60 min ingestion period when compared to the other treatments. Gastrointestinal symptoms were minor for all treatments; the mean total session symptoms ratings (all times summed together) were between 9.8 and 11.6 from a maximum possible rating of 720.<h4>Conclusion</h4>Based on the findings of this investigation, sodium citrate should be ingested over a period of less than 60 min (15, 30 or 45 min), and completed 150-270 min before exercise.Charles S UrwinRodney J SnowLiliana OrellanaDominique CondoGlenn D WadleyAmelia J CarrPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251808 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Charles S Urwin Rodney J Snow Liliana Orellana Dominique Condo Glenn D Wadley Amelia J Carr Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?
description	<h4>Objectives</h4>To compare blood alkalosis, gastrointestinal symptoms and indicators of strong ion difference after ingestion of 500 mg.kg-1 BM sodium citrate over four different periods.<h4>Methods</h4>Sixteen healthy and active participants ingested 500 mg.kg-1 BM sodium citrate in gelatine capsules over a 15, 30, 45 or 60 min period using a randomized cross-over experimental design. Gastrointestinal symptoms questionnaires and venous blood samples were collected before ingestion, immediately post-ingestion, and every 30 min for 480 min post-ingestion. Blood samples were analysed for blood pH, [HCO3-], [Na+], [Cl-] and plasma [citrate]. Linear mixed models were used to estimate the effect of the ingestion protocols.<h4>Results</h4>For all treatments, blood [HCO3-] was significantly elevated above baseline for the entire 480 min post-ingestion period, and peak occurred 180 min post-ingestion. Blood [HCO3-] and pH were significantly elevated above baseline and not significantly below the peak between 150-270 min post-ingestion. Furthermore, blood pH and [HCO3-] were significantly lower for the 60 min ingestion period when compared to the other treatments. Gastrointestinal symptoms were minor for all treatments; the mean total session symptoms ratings (all times summed together) were between 9.8 and 11.6 from a maximum possible rating of 720.<h4>Conclusion</h4>Based on the findings of this investigation, sodium citrate should be ingested over a period of less than 60 min (15, 30 or 45 min), and completed 150-270 min before exercise.
format	article
author	Charles S Urwin Rodney J Snow Liliana Orellana Dominique Condo Glenn D Wadley Amelia J Carr
author_facet	Charles S Urwin Rodney J Snow Liliana Orellana Dominique Condo Glenn D Wadley Amelia J Carr
author_sort	Charles S Urwin
title	Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?
title_short	Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?
title_full	Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?
title_fullStr	Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?
title_full_unstemmed	Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?
title_sort	does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a4c7e9e0a9ff40d5a380fe1d395cbdba
work_keys_str_mv	AT charlessurwin doesvaryingtheingestionperiodofsodiumcitrateinfluencebloodalkalosisandgastrointestinalsymptoms AT rodneyjsnow doesvaryingtheingestionperiodofsodiumcitrateinfluencebloodalkalosisandgastrointestinalsymptoms AT lilianaorellana doesvaryingtheingestionperiodofsodiumcitrateinfluencebloodalkalosisandgastrointestinalsymptoms AT dominiquecondo doesvaryingtheingestionperiodofsodiumcitrateinfluencebloodalkalosisandgastrointestinalsymptoms AT glenndwadley doesvaryingtheingestionperiodofsodiumcitrateinfluencebloodalkalosisandgastrointestinalsymptoms AT ameliajcarr doesvaryingtheingestionperiodofsodiumcitrateinfluencebloodalkalosisandgastrointestinalsymptoms
_version_	1718413942749921280

Does varying the ingestion period of sodium citrate influence blood alkalosis and gastrointestinal symptoms?

Ejemplares similares