Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study

Type 2 diabetes mellitus (T2DM) is considered as a metabolic disease with hyperglycemia. Accumulating investigations have explored the important role of hereditary factors for T2DM occurrence. Some functional microRNA (miR) polymorphisms m ay affect their interactions with target mRNAs and result in...

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Autores principales:	Qiuyu Huang, Hanshen Chen, Fan Xu, Chao Liu, Yafeng Wang, Weifeng Tang, Liangwan Chen
Formato:	article
Lenguaje:	EN
Publicado:	Bioscientifica 2021
Materias:	polymorphism type 2 diabetes mellitus risk microrna Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doi.org/10.1530/EC-21-0261 https://doaj.org/article/a4caa2a813f447b380299681525f0742
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spelling	oai:doaj.org-article:a4caa2a813f447b380299681525f07422021-11-10T07:28:46ZRelationship of microRNA locus with type 2 diabetes mellitus: a case–control studyhttps://doi.org/10.1530/EC-21-02612049-3614https://doaj.org/article/a4caa2a813f447b380299681525f07422021-11-01T00:00:00Zhttps://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0261.xmlhttps://doaj.org/toc/2049-3614Type 2 diabetes mellitus (T2DM) is considered as a metabolic disease with hyperglycemia. Accumulating investigations have explored the important role of hereditary factors for T2DM occurrence. Some functional microRNA (miR) polymorphisms m ay affect their interactions with target mRNAs and result in an aberrant expression. Thus, miR variants might be considered as a biomarker of the susceptibility of T2DM. In this study, we recruited 502 T2DM cases and 782 healthy subjects. We selected miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C and miR-499 rs3746444 A>G loci and carried out an investigation to identify whether these miR loci could influence T2DM occurrence. In this investigation, a Bonferroni correction was harnessed. After adjustment, we found that rs2910164 SNP was a protective factor for T2DM (GG vs CC/CG: adjusted P = 0.010), especially in never drinking (GG vs CC/CG: adjusted P = 0.001) and BMI ≥24 kg/m2 (GG vs CC/CG: adjusted P = 0.002) subgroups. We also identified that rs11614913 SNP was a protective factor for T2DM in smoking subjects (CC/TC vs TT: adjusted P = 0.002). When we analyzed an interaction of SNP–SNP with the susceptibility tof T2DM, rs11614913/ rs3746444, rs2910164/rs3746444 and rs11614913/rs2910164 combinations were not associated with the risk of T2DM. In summary, this study highlights that rs2910164 SNP decreases the susceptibility of T2DM, especially in BMI ≥24 kg/m2 and never drinking subgroups. In addition, we also identify that rs11614913 C allele decreases the susceptibility of T2DM significantly in smoking subgroup.Qiuyu HuangHanshen ChenFan XuChao LiuYafeng WangWeifeng TangLiangwan ChenBioscientificaarticlepolymorphismtype 2 diabetes mellitusriskmicrornaDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Connections, Vol 10, Iss 11, Pp 1393-1402 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymorphism type 2 diabetes mellitus risk microrna Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	polymorphism type 2 diabetes mellitus risk microrna Diseases of the endocrine glands. Clinical endocrinology RC648-665 Qiuyu Huang Hanshen Chen Fan Xu Chao Liu Yafeng Wang Weifeng Tang Liangwan Chen Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study
description	Type 2 diabetes mellitus (T2DM) is considered as a metabolic disease with hyperglycemia. Accumulating investigations have explored the important role of hereditary factors for T2DM occurrence. Some functional microRNA (miR) polymorphisms m ay affect their interactions with target mRNAs and result in an aberrant expression. Thus, miR variants might be considered as a biomarker of the susceptibility of T2DM. In this study, we recruited 502 T2DM cases and 782 healthy subjects. We selected miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C and miR-499 rs3746444 A>G loci and carried out an investigation to identify whether these miR loci could influence T2DM occurrence. In this investigation, a Bonferroni correction was harnessed. After adjustment, we found that rs2910164 SNP was a protective factor for T2DM (GG vs CC/CG: adjusted P = 0.010), especially in never drinking (GG vs CC/CG: adjusted P = 0.001) and BMI ≥24 kg/m2 (GG vs CC/CG: adjusted P = 0.002) subgroups. We also identified that rs11614913 SNP was a protective factor for T2DM in smoking subjects (CC/TC vs TT: adjusted P = 0.002). When we analyzed an interaction of SNP–SNP with the susceptibility tof T2DM, rs11614913/ rs3746444, rs2910164/rs3746444 and rs11614913/rs2910164 combinations were not associated with the risk of T2DM. In summary, this study highlights that rs2910164 SNP decreases the susceptibility of T2DM, especially in BMI ≥24 kg/m2 and never drinking subgroups. In addition, we also identify that rs11614913 C allele decreases the susceptibility of T2DM significantly in smoking subgroup.
format	article
author	Qiuyu Huang Hanshen Chen Fan Xu Chao Liu Yafeng Wang Weifeng Tang Liangwan Chen
author_facet	Qiuyu Huang Hanshen Chen Fan Xu Chao Liu Yafeng Wang Weifeng Tang Liangwan Chen
author_sort	Qiuyu Huang
title	Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study
title_short	Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study
title_full	Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study
title_fullStr	Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study
title_full_unstemmed	Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study
title_sort	relationship of microrna locus with type 2 diabetes mellitus: a case–control study
publisher	Bioscientifica
publishDate	2021
url	https://doi.org/10.1530/EC-21-0261 https://doaj.org/article/a4caa2a813f447b380299681525f0742
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_version_	1718440496110501888

Relationship of microRNA locus with type 2 diabetes mellitus: a case–control study

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