A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

DNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression.

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Autores principales: Fabio Iannelli, Alessandro Galbiati, Ilaria Capozzo, Quan Nguyen, Brian Magnuson, Flavia Michelini, Giuseppina D’Alessandro, Matteo Cabrini, Marco Roncador, Sofia Francia, Nicola Crosetto, Mats Ljungman, Piero Carninci, Fabrizio d’Adda di Fagagna
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a4cc05be64fb4756ab65972047e8495b
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spelling oai:doaj.org-article:a4cc05be64fb4756ab65972047e8495b2021-12-02T14:42:02ZA damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks10.1038/ncomms156562041-1723https://doaj.org/article/a4cc05be64fb4756ab65972047e8495b2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15656https://doaj.org/toc/2041-1723DNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression.Fabio IannelliAlessandro GalbiatiIlaria CapozzoQuan NguyenBrian MagnusonFlavia MicheliniGiuseppina D’AlessandroMatteo CabriniMarco RoncadorSofia FranciaNicola CrosettoMats LjungmanPiero CarninciFabrizio d’Adda di FagagnaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fabio Iannelli
Alessandro Galbiati
Ilaria Capozzo
Quan Nguyen
Brian Magnuson
Flavia Michelini
Giuseppina D’Alessandro
Matteo Cabrini
Marco Roncador
Sofia Francia
Nicola Crosetto
Mats Ljungman
Piero Carninci
Fabrizio d’Adda di Fagagna
A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
description DNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression.
format article
author Fabio Iannelli
Alessandro Galbiati
Ilaria Capozzo
Quan Nguyen
Brian Magnuson
Flavia Michelini
Giuseppina D’Alessandro
Matteo Cabrini
Marco Roncador
Sofia Francia
Nicola Crosetto
Mats Ljungman
Piero Carninci
Fabrizio d’Adda di Fagagna
author_facet Fabio Iannelli
Alessandro Galbiati
Ilaria Capozzo
Quan Nguyen
Brian Magnuson
Flavia Michelini
Giuseppina D’Alessandro
Matteo Cabrini
Marco Roncador
Sofia Francia
Nicola Crosetto
Mats Ljungman
Piero Carninci
Fabrizio d’Adda di Fagagna
author_sort Fabio Iannelli
title A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_short A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_full A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_fullStr A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_full_unstemmed A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
title_sort damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped dna double-strand breaks
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a4cc05be64fb4756ab65972047e8495b
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