Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients

Background: Vascular calcification is a common complication in end-stage renal disease patients and the leading cause of morbidity and mortality. Aim of the work: The current work aimed to evaluate the possible relationship between vitamin D receptor gene polymorphism FokI with fetuin-A and intact p...

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Autores principales:	Fatma Ibrahim Mayah, Hayam Hamza Mansour, Ragaa Ramadan Mohamed, Nadia Kamal Marey, Khaled Younis Mohammed, Amr Mohamed Ibrahim, Tarek Fakhr eldeen Osman
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	vascular calcification vitamin d receptor polymorphism foki fetuin-a parathormone hormone Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a4cc3527f5074082b51d7f419ef44fb0
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spelling	oai:doaj.org-article:a4cc3527f5074082b51d7f419ef44fb02021-12-02T14:06:31ZRelationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients2636-41742682-378010.21608/ijma.2020.31335.1130https://doaj.org/article/a4cc3527f5074082b51d7f419ef44fb02021-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_109400_9cde47bdb8999b0fe5c5baab082f051b.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Vascular calcification is a common complication in end-stage renal disease patients and the leading cause of morbidity and mortality. Aim of the work: The current work aimed to evaluate the possible relationship between vitamin D receptor gene polymorphism FokI with fetuin-A and intact parathormone hormone in Egyptian hemodialysis patients. Patient and Methods: This study is a cross-sectional study including 50 hemodialysis patients attending the hemodialysis unit in Al-Zahra University Hospital and 30 apparently healthy persons as a control group. For all studied subjects, a detailed history was taken, physical examination, carotid intima-media thickness by carotid duplex, echocardiography, Laboratory investigations included serum levels of calcium, phosphorus, iPTH, fetuin, and genotype frequency by PCR Results: There was a highly significant increase in carotid intimal media thickness in the patient group Vs. control group & a highly significant decrease in serum Fetuin-A in the patient's group Vs. control group. There was a significant difference in the genotype distribution of FokI polymorphism among patients and control. There were significant negative relationships between FF genotype and iPTH and a highly significant negative correlation between serum fetuin-A and iPTH in the patient group. Conclusion: Vitamin D receptor gene FokI polymorphism FF genotyping is more frequent in hemodialysis patients who have higher iPTH and lower fetuin-A levels, which could identify the high-risk group susceptible to vascular calcification in hemodialysis patients. Further studies are needed.Fatma Ibrahim MayahHayam Hamza MansourRagaa Ramadan MohamedNadia Kamal MareyKhaled Younis MohammedAmr Mohamed IbrahimTarek Fakhr eldeen OsmanAl-Azhar University, Faculty of Medicine (Damietta)articlevascular calcificationvitamin d receptor polymorphismfokifetuin-aparathormone hormoneMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 1, Pp 967-975 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vascular calcification vitamin d receptor polymorphism foki fetuin-a parathormone hormone Medicine (General) R5-920
spellingShingle	vascular calcification vitamin d receptor polymorphism foki fetuin-a parathormone hormone Medicine (General) R5-920 Fatma Ibrahim Mayah Hayam Hamza Mansour Ragaa Ramadan Mohamed Nadia Kamal Marey Khaled Younis Mohammed Amr Mohamed Ibrahim Tarek Fakhr eldeen Osman Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients
description	Background: Vascular calcification is a common complication in end-stage renal disease patients and the leading cause of morbidity and mortality. Aim of the work: The current work aimed to evaluate the possible relationship between vitamin D receptor gene polymorphism FokI with fetuin-A and intact parathormone hormone in Egyptian hemodialysis patients. Patient and Methods: This study is a cross-sectional study including 50 hemodialysis patients attending the hemodialysis unit in Al-Zahra University Hospital and 30 apparently healthy persons as a control group. For all studied subjects, a detailed history was taken, physical examination, carotid intima-media thickness by carotid duplex, echocardiography, Laboratory investigations included serum levels of calcium, phosphorus, iPTH, fetuin, and genotype frequency by PCR Results: There was a highly significant increase in carotid intimal media thickness in the patient group Vs. control group & a highly significant decrease in serum Fetuin-A in the patient's group Vs. control group. There was a significant difference in the genotype distribution of FokI polymorphism among patients and control. There were significant negative relationships between FF genotype and iPTH and a highly significant negative correlation between serum fetuin-A and iPTH in the patient group. Conclusion: Vitamin D receptor gene FokI polymorphism FF genotyping is more frequent in hemodialysis patients who have higher iPTH and lower fetuin-A levels, which could identify the high-risk group susceptible to vascular calcification in hemodialysis patients. Further studies are needed.
format	article
author	Fatma Ibrahim Mayah Hayam Hamza Mansour Ragaa Ramadan Mohamed Nadia Kamal Marey Khaled Younis Mohammed Amr Mohamed Ibrahim Tarek Fakhr eldeen Osman
author_facet	Fatma Ibrahim Mayah Hayam Hamza Mansour Ragaa Ramadan Mohamed Nadia Kamal Marey Khaled Younis Mohammed Amr Mohamed Ibrahim Tarek Fakhr eldeen Osman
author_sort	Fatma Ibrahim Mayah
title	Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients
title_short	Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients
title_full	Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients
title_fullStr	Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients
title_full_unstemmed	Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients
title_sort	relationship between vitamin-d receptor gene polymorphism foki and fetuin- a as a marker of vascular calcification in egyptian hemodialysis patients
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/a4cc3527f5074082b51d7f419ef44fb0
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Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients

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