Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population.
<h4>Background</h4>Recent genome-wide association studies (GWAS) have mapped several novel loci influencing blood lipid levels in Caucasians. We sought to explore whether the genetic variants at newly identified lipid-associated loci were associated with CHD susceptibility in a Chinese H...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2011
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a4cd428bf535475780734d4fb6418c1a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a4cd428bf535475780734d4fb6418c1a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a4cd428bf535475780734d4fb6418c1a2021-11-18T07:34:23ZGenetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population.1932-620310.1371/journal.pone.0027481https://doaj.org/article/a4cd428bf535475780734d4fb6418c1a2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22110658/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recent genome-wide association studies (GWAS) have mapped several novel loci influencing blood lipid levels in Caucasians. We sought to explore whether the genetic variants at newly identified lipid-associated loci were associated with CHD susceptibility in a Chinese Han population.<h4>Methodology/principal findings</h4>We conducted a two-stage case-control study in a Chinese Han population. The first-stage, consisting of 1,376 CHD cases and 1,376 sex and age- frequency matched controls, examined 5 novel lipid-associated single-nucleotide polymorphisms (SNPs) identified from GWAS among Caucasians in relation to CHD risk in Chinese. We then validated significant SNPs in the second-stage, consisting of 1,269 cases and 2,745 controls. We also tested associations between SNPs within the five novel loci and blood lipid levels in 4,121 controls. We identified two novel SNPs (rs599839 in CELSR2-PSRC1-SORT1 and rs16996148 in NCAN-CILP2) that were significantly associated with reduced CHD risk in Chinese (odds ratios (95% confidence intervals) in the dominant model 0.76 (0.61-0.90; P = 0.001), 0.67 (0.57-0.77; P = 3.4×10(-8)), respectively). Multiple linear regression analyses using dominant model showed that rs599839 was significantly associated with decreased LDL levels (P = 0.022) and rs16996148 was significantly associated with increased LDL and HDL levels (P = 2.9×10(-4) and 0.001, respectively).<h4>Conclusions/significance</h4>We identified two novel SNPs (rs599839 and rs16996148) at newly identified lipid-associated loci that were significantly associated with CHD susceptibility in a Chinese Han population.Li ZhouHu DingXiaomin ZhangMeian HeSuli HuangYujun XuYing ShiGuanglin CuiLongxian ChengQing K WangFrank B HuDaowen WangTangchun WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27481 (2011) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Li Zhou Hu Ding Xiaomin Zhang Meian He Suli Huang Yujun Xu Ying Shi Guanglin Cui Longxian Cheng Qing K Wang Frank B Hu Daowen Wang Tangchun Wu Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population. |
| description |
<h4>Background</h4>Recent genome-wide association studies (GWAS) have mapped several novel loci influencing blood lipid levels in Caucasians. We sought to explore whether the genetic variants at newly identified lipid-associated loci were associated with CHD susceptibility in a Chinese Han population.<h4>Methodology/principal findings</h4>We conducted a two-stage case-control study in a Chinese Han population. The first-stage, consisting of 1,376 CHD cases and 1,376 sex and age- frequency matched controls, examined 5 novel lipid-associated single-nucleotide polymorphisms (SNPs) identified from GWAS among Caucasians in relation to CHD risk in Chinese. We then validated significant SNPs in the second-stage, consisting of 1,269 cases and 2,745 controls. We also tested associations between SNPs within the five novel loci and blood lipid levels in 4,121 controls. We identified two novel SNPs (rs599839 in CELSR2-PSRC1-SORT1 and rs16996148 in NCAN-CILP2) that were significantly associated with reduced CHD risk in Chinese (odds ratios (95% confidence intervals) in the dominant model 0.76 (0.61-0.90; P = 0.001), 0.67 (0.57-0.77; P = 3.4×10(-8)), respectively). Multiple linear regression analyses using dominant model showed that rs599839 was significantly associated with decreased LDL levels (P = 0.022) and rs16996148 was significantly associated with increased LDL and HDL levels (P = 2.9×10(-4) and 0.001, respectively).<h4>Conclusions/significance</h4>We identified two novel SNPs (rs599839 and rs16996148) at newly identified lipid-associated loci that were significantly associated with CHD susceptibility in a Chinese Han population. |
| format |
article |
| author |
Li Zhou Hu Ding Xiaomin Zhang Meian He Suli Huang Yujun Xu Ying Shi Guanglin Cui Longxian Cheng Qing K Wang Frank B Hu Daowen Wang Tangchun Wu |
| author_facet |
Li Zhou Hu Ding Xiaomin Zhang Meian He Suli Huang Yujun Xu Ying Shi Guanglin Cui Longxian Cheng Qing K Wang Frank B Hu Daowen Wang Tangchun Wu |
| author_sort |
Li Zhou |
| title |
Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population. |
| title_short |
Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population. |
| title_full |
Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population. |
| title_fullStr |
Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population. |
| title_full_unstemmed |
Genetic variants at newly identified lipid loci are associated with coronary heart disease in a Chinese Han population. |
| title_sort |
genetic variants at newly identified lipid loci are associated with coronary heart disease in a chinese han population. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/a4cd428bf535475780734d4fb6418c1a |
| work_keys_str_mv |
AT lizhou geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT huding geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT xiaominzhang geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT meianhe geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT sulihuang geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT yujunxu geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT yingshi geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT guanglincui geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT longxiancheng geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT qingkwang geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT frankbhu geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT daowenwang geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation AT tangchunwu geneticvariantsatnewlyidentifiedlipidlociareassociatedwithcoronaryheartdiseaseinachinesehanpopulation |
| _version_ |
1718423305446227968 |