PTPσ inhibitors promote hematopoietic stem cell regeneration

Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoietic stem cell regeneration via induction of the RAC...

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Autores principales:	Yurun Zhang, Martina Roos, Heather Himburg, Christina M. Termini, Mamle Quarmyne, Michelle Li, Liman Zhao, Jenny Kan, Tiancheng Fang, Xiao Yan, Katherine Pohl, Emelyne Diers, Hyo Jin Gim, Robert Damoiseaux, Julian Whitelegge, William McBride, Michael E. Jung, John P. Chute
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4cd7b0d3b6b453f9917108aabe1cec2
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spelling	oai:doaj.org-article:a4cd7b0d3b6b453f9917108aabe1cec22021-12-02T17:32:24ZPTPσ inhibitors promote hematopoietic stem cell regeneration10.1038/s41467-019-11490-52041-1723https://doaj.org/article/a4cd7b0d3b6b453f9917108aabe1cec22019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11490-5https://doaj.org/toc/2041-1723Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoietic stem cell regeneration via induction of the RAC pathway and BCL-XL.Yurun ZhangMartina RoosHeather HimburgChristina M. TerminiMamle QuarmyneMichelle LiLiman ZhaoJenny KanTiancheng FangXiao YanKatherine PohlEmelyne DiersHyo Jin GimRobert DamoiseauxJulian WhiteleggeWilliam McBrideMichael E. JungJohn P. ChuteNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yurun Zhang Martina Roos Heather Himburg Christina M. Termini Mamle Quarmyne Michelle Li Liman Zhao Jenny Kan Tiancheng Fang Xiao Yan Katherine Pohl Emelyne Diers Hyo Jin Gim Robert Damoiseaux Julian Whitelegge William McBride Michael E. Jung John P. Chute PTPσ inhibitors promote hematopoietic stem cell regeneration
description	Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoietic stem cell regeneration via induction of the RAC pathway and BCL-XL.
format	article
author	Yurun Zhang Martina Roos Heather Himburg Christina M. Termini Mamle Quarmyne Michelle Li Liman Zhao Jenny Kan Tiancheng Fang Xiao Yan Katherine Pohl Emelyne Diers Hyo Jin Gim Robert Damoiseaux Julian Whitelegge William McBride Michael E. Jung John P. Chute
author_facet	Yurun Zhang Martina Roos Heather Himburg Christina M. Termini Mamle Quarmyne Michelle Li Liman Zhao Jenny Kan Tiancheng Fang Xiao Yan Katherine Pohl Emelyne Diers Hyo Jin Gim Robert Damoiseaux Julian Whitelegge William McBride Michael E. Jung John P. Chute
author_sort	Yurun Zhang
title	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_short	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_full	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_fullStr	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_full_unstemmed	PTPσ inhibitors promote hematopoietic stem cell regeneration
title_sort	ptpσ inhibitors promote hematopoietic stem cell regeneration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a4cd7b0d3b6b453f9917108aabe1cec2
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_version_	1718380326001049600

PTPσ inhibitors promote hematopoietic stem cell regeneration

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