5′-Modifications improve potency and efficacy of DNA donors for precision genome editing

5′-Modifications improve potency and efficacy of DNA donors for precision genome editing

Nuclease-directed genome editing is a powerful tool for investigating physiology and has great promise as a therapeutic approach to correct mutations that cause disease. In its most precise form, genome editing can use cellular homology-directed repair (HDR) pathways to insert information from an ex...

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Bibliographic Details
Main Authors: Krishna S Ghanta, Zexiang Chen, Aamir Mir, Gregoriy A Dokshin, Pranathi M Krishnamurthy, Yeonsoo Yoon, Judith Gallant, Ping Xu, Xiao-Ou Zhang, Ahmet Rasit Ozturk, Masahiro Shin, Feston Idrizi, Pengpeng Liu, Hassan Gneid, Alireza Edraki, Nathan D Lawson, Jaime A Rivera-Pérez, Erik J Sontheimer, Jonathan K Watts, Craig C Mello
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
CRISPR
HDR
modified donors
chemical modifications
genome editing
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/a4d2a8d974e94e189ee441394236bb61
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