Exogenous Stimulation of Type I Interferon Protects Mice with Chronic Granulomatous Disease from Aspergillosis through Early Recruitment of Host-Protective Neutrophils into the Lung

Exogenous Stimulation of Type I Interferon Protects Mice with Chronic Granulomatous Disease from Aspergillosis through Early Recruitment of Host-Protective Neutrophils into the Lung

ABSTRACT Invasive aspergillosis (IA) remains the primary cause of morbidity and mortality in chronic granulomatous disease (CGD) patients, often due to infection by Aspergillus species refractory to antifungals. This motivates the search for alternative treatments, including immunotherapy. We invest...

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Autores principales: Seyedmojtaba Seyedmousavi, Michael J. Davis, Janyce A. Sugui, Tzvia Pinkhasov, Shannon Moyer, Andres M. Salazar, Yun C. Chang, Kyung J. Kwon-Chung
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
Aspergillus fumigatus
Aspergillus nidulans
Aspergillus tanneri
poly(I:C) (PICLC)
chronic granulomatous disease (CGD)
conidia
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/a4d609af11e54c1b9d0098a728cb089a
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