Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.

We assessed abnormalities within the principal brain resting state networks (RSNs) in patients with Leber's hereditary optic neuropathy (LHON) to define whether functional abnormalities in this disease are limited to the visual system or, conversely, tend to be more diffuse. We also defined the...

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Autores principales:	Maria A Rocca, Paola Valsasina, Elisabetta Pagani, Stefania Bianchi-Marzoli, Jacopo Milesi, Andrea Falini, Giancarlo Comi, Massimo Filippi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4d8aa7f4abb44148f32195cddff65d9
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spelling	oai:doaj.org-article:a4d8aa7f4abb44148f32195cddff65d92021-11-18T06:58:57ZExtra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.1932-620310.1371/journal.pone.0017081https://doaj.org/article/a4d8aa7f4abb44148f32195cddff65d92011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21347331/?tool=EBIhttps://doaj.org/toc/1932-6203We assessed abnormalities within the principal brain resting state networks (RSNs) in patients with Leber's hereditary optic neuropathy (LHON) to define whether functional abnormalities in this disease are limited to the visual system or, conversely, tend to be more diffuse. We also defined the structural substrates of fMRI changes using a connectivity-based analysis of diffusion tensor (DT) MRI data. Neuro-ophthalmologic assessment, DT MRI and RS fMRI data were acquired from 13 LHON patients and 13 healthy controls. RS fMRI data were analyzed using independent component analysis and SPM5. A DT MRI connectivity-based parcellation analysis was performed using the primary visual and auditory cortices, bilaterally, as seed regions. Compared to controls, LHON patients had a significant increase of RS fluctuations in the primary visual and auditory cortices, bilaterally. They also showed decreased RS fluctuations in the right lateral occipital cortex and right temporal occipital fusiform cortex. Abnormalities of RS fluctuations were correlated significantly with retinal damage and disease duration. The DT MRI connectivity-based parcellation identified a higher number of clusters in the right auditory cortex in LHON vs. controls. Differences of cluster-centroid profiles were found between the two groups for all the four seeds analyzed. For three of these areas, a correspondence was found between abnormalities of functional and structural connectivities. These results suggest that functional and structural abnormalities extend beyond the visual network in LHON patients. Such abnormalities also involve the auditory network, thus corroborating the notion of a cross-modal plasticity between these sensory modalities in patients with severe visual deficits.Maria A RoccaPaola ValsasinaElisabetta PaganiStefania Bianchi-MarzoliJacopo MilesiAndrea FaliniGiancarlo ComiMassimo FilippiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17081 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria A Rocca Paola Valsasina Elisabetta Pagani Stefania Bianchi-Marzoli Jacopo Milesi Andrea Falini Giancarlo Comi Massimo Filippi Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.
description	We assessed abnormalities within the principal brain resting state networks (RSNs) in patients with Leber's hereditary optic neuropathy (LHON) to define whether functional abnormalities in this disease are limited to the visual system or, conversely, tend to be more diffuse. We also defined the structural substrates of fMRI changes using a connectivity-based analysis of diffusion tensor (DT) MRI data. Neuro-ophthalmologic assessment, DT MRI and RS fMRI data were acquired from 13 LHON patients and 13 healthy controls. RS fMRI data were analyzed using independent component analysis and SPM5. A DT MRI connectivity-based parcellation analysis was performed using the primary visual and auditory cortices, bilaterally, as seed regions. Compared to controls, LHON patients had a significant increase of RS fluctuations in the primary visual and auditory cortices, bilaterally. They also showed decreased RS fluctuations in the right lateral occipital cortex and right temporal occipital fusiform cortex. Abnormalities of RS fluctuations were correlated significantly with retinal damage and disease duration. The DT MRI connectivity-based parcellation identified a higher number of clusters in the right auditory cortex in LHON vs. controls. Differences of cluster-centroid profiles were found between the two groups for all the four seeds analyzed. For three of these areas, a correspondence was found between abnormalities of functional and structural connectivities. These results suggest that functional and structural abnormalities extend beyond the visual network in LHON patients. Such abnormalities also involve the auditory network, thus corroborating the notion of a cross-modal plasticity between these sensory modalities in patients with severe visual deficits.
format	article
author	Maria A Rocca Paola Valsasina Elisabetta Pagani Stefania Bianchi-Marzoli Jacopo Milesi Andrea Falini Giancarlo Comi Massimo Filippi
author_facet	Maria A Rocca Paola Valsasina Elisabetta Pagani Stefania Bianchi-Marzoli Jacopo Milesi Andrea Falini Giancarlo Comi Massimo Filippi
author_sort	Maria A Rocca
title	Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.
title_short	Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.
title_full	Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.
title_fullStr	Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.
title_full_unstemmed	Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.
title_sort	extra-visual functional and structural connection abnormalities in leber's hereditary optic neuropathy.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/a4d8aa7f4abb44148f32195cddff65d9
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Extra-visual functional and structural connection abnormalities in Leber's hereditary optic neuropathy.

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