Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)—Comparison With ISCVT Cohort
Introduction: Cerebral venous thrombosis (CVT) is a rare disease with highly variable clinical presentation and outcome. Etiological assessment may be negative. The clinical and radiological presentation and evolution can be highly variable. The mechanisms involved in this variability remain unknown...
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oai:doaj.org-article:a4e1b59a1ccb48cb9ca3e5e5189a42772021-11-08T07:49:53ZCerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)—Comparison With ISCVT Cohort1664-229510.3389/fneur.2021.753110https://doaj.org/article/a4e1b59a1ccb48cb9ca3e5e5189a42772021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.753110/fullhttps://doaj.org/toc/1664-2295Introduction: Cerebral venous thrombosis (CVT) is a rare disease with highly variable clinical presentation and outcome. Etiological assessment may be negative. The clinical and radiological presentation and evolution can be highly variable. The mechanisms involved in this variability remain unknown.Objective: The aim of this multicenter French study registered on ClinicalTrials.gov (NCT02013635) was therefore to prospectively recruit a cohort of patients with cerebral venous thrombosis (FPCCVT) in order to study thrombin generation and clot degradation, and to evaluate their influence on clinical radiological characteristics. The first part of the study was to compare our cohort with a reference cohort.Methods: This prospective, multicenter, French study was conducted from July 2011 to September 2016. Consecutive patients (aged >15 years) referred to the stroke units of 21 French centers and who had a diagnosis of symptomatic CVT were included. All patients gave their written informed consent. The diagnosis of CVT had to be confirmed by imaging. Clinical, radiological, biological, and etiological characteristics were recorded at baseline, at acute phase, at 3 months and at last follow-up visit. Thrombophilia screening and the choice of treatment were performed by the attending physician. All data were compared with data from the International Study on CVT published by Ferro et al.Results: Two hundred thirty-one patients were included: 117 (50.6%) had isolated intracranial hypertension, 96 (41.5%) had focal syndrome. During hospitalization, 229 (99.1%) patients received anticoagulant treatment. Median length of hospital stay was 10 days. Five patients died during hospitalization (2.2%). At 3 months, 216 patients (97.0%) had follow-up with neurological data based on an outpatient visit. The mean duration of antithrombotic treatment was 9 months, and the mean time to last follow-up was 10.5 months. At the end of follow-up, eight patients had died, and 26 patients were lost to follow-up. At least one risk factor was identified in 200 patients.Conclusions: We demonstrated that the FPCCVT cohort had radiological, biological, and etiological characteristics similar to the historical ISCVT cohort. Nevertheless, the initial clinical presentation was less severe in our study probably due to an improvement in diagnostic methods between the two studies.Aude Triquenot BaganIsabelle CrassardLudovic DrouetMarianne Barbieux-GuillotRaphaël MarluEmmanuelle Robinet-BorgominoPierre-Emmanuel MorangeValérie WolffLelia GrunebaumFrédéric KlapczynskiElisabeth André-KerneisFernando PicoBrigitte Martin-BastenaireEmmanuel EllieFanny MenardFrançois RouanetGeneviève FreyburgerGaëlle GodenècheHong-An AllanoThierry MoulinGuillaume MoureyLaurent DerexMicheline BerruyerGwénaëlle RunavotCatherine TrichetFausto ViaderAgnès Le QuerrecThomas Tarek HuseinSophie Cluet-DennetiereFrancisco Macian-MontoroMagali DonnardBenoît GuillonCatherine TernisienMathieu ZuberSophie LaplanchePhilippe TassanJean-Yves PeeltierSandrine CanapleBertrand RousselNicolas GaillardEmilie ScavazzaVéronique Le Cam DuchezFrontiers Media S.A.articlecerebral veinsthrombosisFrench cohortprospective observational studysinusNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021) |
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cerebral veins thrombosis French cohort prospective observational study sinus Neurology. Diseases of the nervous system RC346-429 |
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cerebral veins thrombosis French cohort prospective observational study sinus Neurology. Diseases of the nervous system RC346-429 Aude Triquenot Bagan Isabelle Crassard Ludovic Drouet Marianne Barbieux-Guillot Raphaël Marlu Emmanuelle Robinet-Borgomino Pierre-Emmanuel Morange Valérie Wolff Lelia Grunebaum Frédéric Klapczynski Elisabeth André-Kerneis Fernando Pico Brigitte Martin-Bastenaire Emmanuel Ellie Fanny Menard François Rouanet Geneviève Freyburger Gaëlle Godenèche Hong-An Allano Thierry Moulin Guillaume Mourey Laurent Derex Micheline Berruyer Gwénaëlle Runavot Catherine Trichet Fausto Viader Agnès Le Querrec Thomas Tarek Husein Sophie Cluet-Dennetiere Francisco Macian-Montoro Magali Donnard Benoît Guillon Catherine Ternisien Mathieu Zuber Sophie Laplanche Philippe Tassan Jean-Yves Peeltier Sandrine Canaple Bertrand Roussel Nicolas Gaillard Emilie Scavazza Véronique Le Cam Duchez Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)—Comparison With ISCVT Cohort |
| description |
Introduction: Cerebral venous thrombosis (CVT) is a rare disease with highly variable clinical presentation and outcome. Etiological assessment may be negative. The clinical and radiological presentation and evolution can be highly variable. The mechanisms involved in this variability remain unknown.Objective: The aim of this multicenter French study registered on ClinicalTrials.gov (NCT02013635) was therefore to prospectively recruit a cohort of patients with cerebral venous thrombosis (FPCCVT) in order to study thrombin generation and clot degradation, and to evaluate their influence on clinical radiological characteristics. The first part of the study was to compare our cohort with a reference cohort.Methods: This prospective, multicenter, French study was conducted from July 2011 to September 2016. Consecutive patients (aged >15 years) referred to the stroke units of 21 French centers and who had a diagnosis of symptomatic CVT were included. All patients gave their written informed consent. The diagnosis of CVT had to be confirmed by imaging. Clinical, radiological, biological, and etiological characteristics were recorded at baseline, at acute phase, at 3 months and at last follow-up visit. Thrombophilia screening and the choice of treatment were performed by the attending physician. All data were compared with data from the International Study on CVT published by Ferro et al.Results: Two hundred thirty-one patients were included: 117 (50.6%) had isolated intracranial hypertension, 96 (41.5%) had focal syndrome. During hospitalization, 229 (99.1%) patients received anticoagulant treatment. Median length of hospital stay was 10 days. Five patients died during hospitalization (2.2%). At 3 months, 216 patients (97.0%) had follow-up with neurological data based on an outpatient visit. The mean duration of antithrombotic treatment was 9 months, and the mean time to last follow-up was 10.5 months. At the end of follow-up, eight patients had died, and 26 patients were lost to follow-up. At least one risk factor was identified in 200 patients.Conclusions: We demonstrated that the FPCCVT cohort had radiological, biological, and etiological characteristics similar to the historical ISCVT cohort. Nevertheless, the initial clinical presentation was less severe in our study probably due to an improvement in diagnostic methods between the two studies. |
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| author |
Aude Triquenot Bagan Isabelle Crassard Ludovic Drouet Marianne Barbieux-Guillot Raphaël Marlu Emmanuelle Robinet-Borgomino Pierre-Emmanuel Morange Valérie Wolff Lelia Grunebaum Frédéric Klapczynski Elisabeth André-Kerneis Fernando Pico Brigitte Martin-Bastenaire Emmanuel Ellie Fanny Menard François Rouanet Geneviève Freyburger Gaëlle Godenèche Hong-An Allano Thierry Moulin Guillaume Mourey Laurent Derex Micheline Berruyer Gwénaëlle Runavot Catherine Trichet Fausto Viader Agnès Le Querrec Thomas Tarek Husein Sophie Cluet-Dennetiere Francisco Macian-Montoro Magali Donnard Benoît Guillon Catherine Ternisien Mathieu Zuber Sophie Laplanche Philippe Tassan Jean-Yves Peeltier Sandrine Canaple Bertrand Roussel Nicolas Gaillard Emilie Scavazza Véronique Le Cam Duchez |
| author_facet |
Aude Triquenot Bagan Isabelle Crassard Ludovic Drouet Marianne Barbieux-Guillot Raphaël Marlu Emmanuelle Robinet-Borgomino Pierre-Emmanuel Morange Valérie Wolff Lelia Grunebaum Frédéric Klapczynski Elisabeth André-Kerneis Fernando Pico Brigitte Martin-Bastenaire Emmanuel Ellie Fanny Menard François Rouanet Geneviève Freyburger Gaëlle Godenèche Hong-An Allano Thierry Moulin Guillaume Mourey Laurent Derex Micheline Berruyer Gwénaëlle Runavot Catherine Trichet Fausto Viader Agnès Le Querrec Thomas Tarek Husein Sophie Cluet-Dennetiere Francisco Macian-Montoro Magali Donnard Benoît Guillon Catherine Ternisien Mathieu Zuber Sophie Laplanche Philippe Tassan Jean-Yves Peeltier Sandrine Canaple Bertrand Roussel Nicolas Gaillard Emilie Scavazza Véronique Le Cam Duchez |
| author_sort |
Aude Triquenot Bagan |
| title |
Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)—Comparison With ISCVT Cohort |
| title_short |
Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)—Comparison With ISCVT Cohort |
| title_full |
Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)—Comparison With ISCVT Cohort |
| title_fullStr |
Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)—Comparison With ISCVT Cohort |
| title_full_unstemmed |
Cerebral Venous Thrombosis: Clinical, Radiological, Biological, and Etiological Characteristics of a French Prospective Cohort (FPCCVT)—Comparison With ISCVT Cohort |
| title_sort |
cerebral venous thrombosis: clinical, radiological, biological, and etiological characteristics of a french prospective cohort (fpccvt)—comparison with iscvt cohort |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/a4e1b59a1ccb48cb9ca3e5e5189a4277 |
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