Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen

Aerotaxis, chemotaxis towards oxygen, occurs in bacteria and likely in cancer cells. Here the authors find that confined cells from different tissues escape hypoxia by aerotaxis, a process independent of mitochondria and the HIF pathway, and dependent on EGF receptor interpretation of a ROS gradient...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mathieu Deygas, Rudy Gadet, Germain Gillet, Ruth Rimokh, Philippe Gonzalo, Ivan Mikaelian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4e51a68e65c470bac0c6a0d616c2971
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a4e51a68e65c470bac0c6a0d616c2971
record_format	dspace
spelling	oai:doaj.org-article:a4e51a68e65c470bac0c6a0d616c29712021-12-02T17:31:17ZRedox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen10.1038/s41467-018-06988-32041-1723https://doaj.org/article/a4e51a68e65c470bac0c6a0d616c29712018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06988-3https://doaj.org/toc/2041-1723Aerotaxis, chemotaxis towards oxygen, occurs in bacteria and likely in cancer cells. Here the authors find that confined cells from different tissues escape hypoxia by aerotaxis, a process independent of mitochondria and the HIF pathway, and dependent on EGF receptor interpretation of a ROS gradient in mammary cells.Mathieu DeygasRudy GadetGermain GilletRuth RimokhPhilippe GonzaloIvan MikaelianNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mathieu Deygas Rudy Gadet Germain Gillet Ruth Rimokh Philippe Gonzalo Ivan Mikaelian Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen
description	Aerotaxis, chemotaxis towards oxygen, occurs in bacteria and likely in cancer cells. Here the authors find that confined cells from different tissues escape hypoxia by aerotaxis, a process independent of mitochondria and the HIF pathway, and dependent on EGF receptor interpretation of a ROS gradient in mammary cells.
format	article
author	Mathieu Deygas Rudy Gadet Germain Gillet Ruth Rimokh Philippe Gonzalo Ivan Mikaelian
author_facet	Mathieu Deygas Rudy Gadet Germain Gillet Ruth Rimokh Philippe Gonzalo Ivan Mikaelian
author_sort	Mathieu Deygas
title	Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen
title_short	Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen
title_full	Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen
title_fullStr	Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen
title_full_unstemmed	Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen
title_sort	redox regulation of egfr steers migration of hypoxic mammary cells towards oxygen
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a4e51a68e65c470bac0c6a0d616c2971
work_keys_str_mv	AT mathieudeygas redoxregulationofegfrsteersmigrationofhypoxicmammarycellstowardsoxygen AT rudygadet redoxregulationofegfrsteersmigrationofhypoxicmammarycellstowardsoxygen AT germaingillet redoxregulationofegfrsteersmigrationofhypoxicmammarycellstowardsoxygen AT ruthrimokh redoxregulationofegfrsteersmigrationofhypoxicmammarycellstowardsoxygen AT philippegonzalo redoxregulationofegfrsteersmigrationofhypoxicmammarycellstowardsoxygen AT ivanmikaelian redoxregulationofegfrsteersmigrationofhypoxicmammarycellstowardsoxygen
_version_	1718380690499698688

Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen

Ejemplares similares