Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen

Aerotaxis, chemotaxis towards oxygen, occurs in bacteria and likely in cancer cells. Here the authors find that confined cells from different tissues escape hypoxia by aerotaxis, a process independent of mitochondria and the HIF pathway, and dependent on EGF receptor interpretation of a ROS gradient...

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Autores principales: Mathieu Deygas, Rudy Gadet, Germain Gillet, Ruth Rimokh, Philippe Gonzalo, Ivan Mikaelian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a4e51a68e65c470bac0c6a0d616c2971
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