Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions

Multimodal monitoring has been gaining traction in the critical care of patients following traumatic brain injury (TBI). Through providing a deeper understanding of the individual patient’s comprehensive physiologic state, or “physiome,” following injury, these methods hold the promise of improving...

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Autores principales:	Alwyn Gomez, Amanjyot Singh Sainbhi, Logan Froese, Carleen Batson, Arsalan Alizadeh, Asher A. Mendelson, Frederick A. Zeiler
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	traumatic brain injury near-infrared spectroscopy cerebrovascular reactivity multi-modal monitoring precision medicine Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a4e9bffb6de84c4896eabc5863df5a06
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spelling	oai:doaj.org-article:a4e9bffb6de84c4896eabc5863df5a062021-11-05T10:36:39ZNear Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions1663-981210.3389/fphar.2021.719501https://doaj.org/article/a4e9bffb6de84c4896eabc5863df5a062021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.719501/fullhttps://doaj.org/toc/1663-9812Multimodal monitoring has been gaining traction in the critical care of patients following traumatic brain injury (TBI). Through providing a deeper understanding of the individual patient’s comprehensive physiologic state, or “physiome,” following injury, these methods hold the promise of improving personalized care and advancing precision medicine. One of the modalities being explored in TBI care is near-infrared spectroscopy (NIRS), given it’s non-invasive nature and ability to interrogate microvascular and tissue oxygen metabolism. In this narrative review, we begin by discussing the principles of NIRS technology, including spatially, frequency, and time-resolved variants. Subsequently, the applications of NIRS in various phases of clinical care following TBI are explored. These applications include the pre-hospital, intraoperative, neurocritical care, and outpatient/rehabilitation setting. The utility of NIRS to predict functional outcomes and evaluate dysfunctional cerebrovascular reactivity is also discussed. Finally, future applications and potential advancements in NIRS-based physiologic monitoring of TBI patients are presented, with a description of the potential integration with other omics biomarkers.Alwyn GomezAlwyn GomezAmanjyot Singh SainbhiLogan FroeseCarleen BatsonArsalan AlizadehAsher A. MendelsonAsher A. MendelsonFrederick A. ZeilerFrederick A. ZeilerFrederick A. ZeilerFrederick A. ZeilerFrederick A. ZeilerFrontiers Media S.A.articletraumatic brain injurynear-infrared spectroscopycerebrovascular reactivitymulti-modal monitoringprecision medicineTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	traumatic brain injury near-infrared spectroscopy cerebrovascular reactivity multi-modal monitoring precision medicine Therapeutics. Pharmacology RM1-950
spellingShingle	traumatic brain injury near-infrared spectroscopy cerebrovascular reactivity multi-modal monitoring precision medicine Therapeutics. Pharmacology RM1-950 Alwyn Gomez Alwyn Gomez Amanjyot Singh Sainbhi Logan Froese Carleen Batson Arsalan Alizadeh Asher A. Mendelson Asher A. Mendelson Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions
description	Multimodal monitoring has been gaining traction in the critical care of patients following traumatic brain injury (TBI). Through providing a deeper understanding of the individual patient’s comprehensive physiologic state, or “physiome,” following injury, these methods hold the promise of improving personalized care and advancing precision medicine. One of the modalities being explored in TBI care is near-infrared spectroscopy (NIRS), given it’s non-invasive nature and ability to interrogate microvascular and tissue oxygen metabolism. In this narrative review, we begin by discussing the principles of NIRS technology, including spatially, frequency, and time-resolved variants. Subsequently, the applications of NIRS in various phases of clinical care following TBI are explored. These applications include the pre-hospital, intraoperative, neurocritical care, and outpatient/rehabilitation setting. The utility of NIRS to predict functional outcomes and evaluate dysfunctional cerebrovascular reactivity is also discussed. Finally, future applications and potential advancements in NIRS-based physiologic monitoring of TBI patients are presented, with a description of the potential integration with other omics biomarkers.
format	article
author	Alwyn Gomez Alwyn Gomez Amanjyot Singh Sainbhi Logan Froese Carleen Batson Arsalan Alizadeh Asher A. Mendelson Asher A. Mendelson Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler
author_facet	Alwyn Gomez Alwyn Gomez Amanjyot Singh Sainbhi Logan Froese Carleen Batson Arsalan Alizadeh Asher A. Mendelson Asher A. Mendelson Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler
author_sort	Alwyn Gomez
title	Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions
title_short	Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions
title_full	Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions
title_fullStr	Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions
title_full_unstemmed	Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions
title_sort	near infrared spectroscopy for high-temporal resolution cerebral physiome characterization in tbi: a narrative review of techniques, applications, and future directions
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a4e9bffb6de84c4896eabc5863df5a06
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Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions

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