Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites

Carboxy-methyl-cellulose (CMC) hydrogels, prepared in the presence of a crosslinker and photoinitiator, were reinforced with 3.7 wt% electrospun PLA fibers to create CMC hydrogel composites. To improve fiber-matrix adhesion, electrospun fiber mats based on hybrids of PLA and amphiphilic block copoly...

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Autores principales:	Xi Zhang, William Megone, Ton Peijs, Julien E. Gautrot
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	electrospun fibers poly(lactide acid) hydrogels composites biomaterials Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/a4e9d12f9749489d8b966f0584ffcf0e
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spelling	oai:doaj.org-article:a4e9d12f9749489d8b966f0584ffcf0e2021-12-02T17:55:39ZFunctionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites2055-033210.1080/20550324.2020.1784600https://doaj.org/article/a4e9d12f9749489d8b966f0584ffcf0e2020-07-01T00:00:00Zhttp://dx.doi.org/10.1080/20550324.2020.1784600https://doaj.org/toc/2055-0332Carboxy-methyl-cellulose (CMC) hydrogels, prepared in the presence of a crosslinker and photoinitiator, were reinforced with 3.7 wt% electrospun PLA fibers to create CMC hydrogel composites. To improve fiber-matrix adhesion, electrospun fiber mats based on hybrids of PLA and amphiphilic block copolymer (BCP) poly(D,L-lactide)-block-poly[2-(dimethylamino)ethyl methacrylate] (PLA-b-PDMAEMA) were produced. The presence of PDMAEMA at the fiber surface induced hydrophilic surface properties, which could be controlled by varying the PDMAEMA chain length. PDMAEMA was quaternized and co-electrospun with PLA fibers, which further enhanced the interaction between fibers and hydrogel matrix via ionic interactions. Physicochemical properties of the electrospun fiber mats and their CMC hydrogel based composites were assessed and revealed a nearly two orders of magnitude increase in modulus. Continuous electrospun fiber mats were chopped into discontinuous fibers to create short fiber reinforced CMC hydrogels. Rheological properties of these reinforced hydrogels incorporating 0.5 wt% discontinuous fibers were evaluated and showed potential as injectable composite systems for biomedical applications.Xi ZhangWilliam MegoneTon PeijsJulien E. GautrotTaylor & Francis Grouparticleelectrospun fiberspoly(lactide acid)hydrogelscompositesbiomaterialsMaterials of engineering and construction. Mechanics of materialsTA401-492Polymers and polymer manufactureTP1080-1185ENNanocomposites, Vol 6, Iss 3, Pp 85-98 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	electrospun fibers poly(lactide acid) hydrogels composites biomaterials Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185
spellingShingle	electrospun fibers poly(lactide acid) hydrogels composites biomaterials Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185 Xi Zhang William Megone Ton Peijs Julien E. Gautrot Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites
description	Carboxy-methyl-cellulose (CMC) hydrogels, prepared in the presence of a crosslinker and photoinitiator, were reinforced with 3.7 wt% electrospun PLA fibers to create CMC hydrogel composites. To improve fiber-matrix adhesion, electrospun fiber mats based on hybrids of PLA and amphiphilic block copolymer (BCP) poly(D,L-lactide)-block-poly[2-(dimethylamino)ethyl methacrylate] (PLA-b-PDMAEMA) were produced. The presence of PDMAEMA at the fiber surface induced hydrophilic surface properties, which could be controlled by varying the PDMAEMA chain length. PDMAEMA was quaternized and co-electrospun with PLA fibers, which further enhanced the interaction between fibers and hydrogel matrix via ionic interactions. Physicochemical properties of the electrospun fiber mats and their CMC hydrogel based composites were assessed and revealed a nearly two orders of magnitude increase in modulus. Continuous electrospun fiber mats were chopped into discontinuous fibers to create short fiber reinforced CMC hydrogels. Rheological properties of these reinforced hydrogels incorporating 0.5 wt% discontinuous fibers were evaluated and showed potential as injectable composite systems for biomedical applications.
format	article
author	Xi Zhang William Megone Ton Peijs Julien E. Gautrot
author_facet	Xi Zhang William Megone Ton Peijs Julien E. Gautrot
author_sort	Xi Zhang
title	Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites
title_short	Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites
title_full	Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites
title_fullStr	Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites
title_full_unstemmed	Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites
title_sort	functionalization of electrospun pla fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/a4e9d12f9749489d8b966f0584ffcf0e
work_keys_str_mv	AT xizhang functionalizationofelectrospunplafibersusingamphiphilicblockcopolymersforuseincarboxymethylcellulosehydrogelcomposites AT williammegone functionalizationofelectrospunplafibersusingamphiphilicblockcopolymersforuseincarboxymethylcellulosehydrogelcomposites AT tonpeijs functionalizationofelectrospunplafibersusingamphiphilicblockcopolymersforuseincarboxymethylcellulosehydrogelcomposites AT julienegautrot functionalizationofelectrospunplafibersusingamphiphilicblockcopolymersforuseincarboxymethylcellulosehydrogelcomposites
_version_	1718379126059958272

Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites

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