Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer

Abstract Objectives The present study used dynamic-contrast enhanced MRI (DCE-MRI) to elucidate possible associations with tumor-infiltrating lymphocytes (TIL), stroma ratio and vimentin expression in head and neck squamous cell cancer (HNSCC). Methods Overall, 26 patients with primary HNSCC of diff...

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Autores principales:	Hans-Jonas Meyer, Anne Kathrin Höhn, Alexey Surov
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Head and neck squamous cell cancer Dynamic contrast enhanced-MRI Tumor infiltrating lymphocyte Histogram analysis Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a4ea0e25ffb74eb28c1f41285ff09534
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spelling	oai:doaj.org-article:a4ea0e25ffb74eb28c1f41285ff095342021-11-21T12:42:32ZAssociations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer10.1186/s40644-021-00429-z1470-7330https://doaj.org/article/a4ea0e25ffb74eb28c1f41285ff095342021-11-01T00:00:00Zhttps://doi.org/10.1186/s40644-021-00429-zhttps://doaj.org/toc/1470-7330Abstract Objectives The present study used dynamic-contrast enhanced MRI (DCE-MRI) to elucidate possible associations with tumor-infiltrating lymphocytes (TIL), stroma ratio and vimentin expression in head and neck squamous cell cancer (HNSCC). Methods Overall, 26 patients with primary HNSCC of different localizations were involved in the study. DCE-MRI was obtained on a 3 T MRI and analyzed with a whole lesion measurement using a histogram approach. TIL- and vimentin-expression was calculated on bioptic samples before any form of treatment. P16 staining was used to define HPV-status. Results Tumor-stroma ratio correlated with entropy derived from Ktrans (r = − 0.52, p = 0.0071) and with kurtosis derived from Ve (r = − 0.53, p = 0.0058). Several Ve derived parameters correlated with expression of TIL within the stroma compartment. TIL within the tumor compartment correlated with entropy derived from Ktrans (r = 0.39, p = 0.047), p90 derived from Ve (r = 0.41, p = 0.036) and skewness derived from Ve (r = 0.41, p = 0.037). Furthermore, these associations were different between HPV positive and negative tumors. Conclusions DCE-MRI might be able to reflect tumor compartments and TIL expression in HNSCC. The most promising parameters were values derived from Ktrans and Ve.Hans-Jonas MeyerAnne Kathrin HöhnAlexey SurovBMCarticleHead and neck squamous cell cancerDynamic contrast enhanced-MRITumor infiltrating lymphocyteHistogram analysisMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Imaging, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Head and neck squamous cell cancer Dynamic contrast enhanced-MRI Tumor infiltrating lymphocyte Histogram analysis Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Head and neck squamous cell cancer Dynamic contrast enhanced-MRI Tumor infiltrating lymphocyte Histogram analysis Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hans-Jonas Meyer Anne Kathrin Höhn Alexey Surov Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer
description	Abstract Objectives The present study used dynamic-contrast enhanced MRI (DCE-MRI) to elucidate possible associations with tumor-infiltrating lymphocytes (TIL), stroma ratio and vimentin expression in head and neck squamous cell cancer (HNSCC). Methods Overall, 26 patients with primary HNSCC of different localizations were involved in the study. DCE-MRI was obtained on a 3 T MRI and analyzed with a whole lesion measurement using a histogram approach. TIL- and vimentin-expression was calculated on bioptic samples before any form of treatment. P16 staining was used to define HPV-status. Results Tumor-stroma ratio correlated with entropy derived from Ktrans (r = − 0.52, p = 0.0071) and with kurtosis derived from Ve (r = − 0.53, p = 0.0058). Several Ve derived parameters correlated with expression of TIL within the stroma compartment. TIL within the tumor compartment correlated with entropy derived from Ktrans (r = 0.39, p = 0.047), p90 derived from Ve (r = 0.41, p = 0.036) and skewness derived from Ve (r = 0.41, p = 0.037). Furthermore, these associations were different between HPV positive and negative tumors. Conclusions DCE-MRI might be able to reflect tumor compartments and TIL expression in HNSCC. The most promising parameters were values derived from Ktrans and Ve.
format	article
author	Hans-Jonas Meyer Anne Kathrin Höhn Alexey Surov
author_facet	Hans-Jonas Meyer Anne Kathrin Höhn Alexey Surov
author_sort	Hans-Jonas Meyer
title	Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer
title_short	Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer
title_full	Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer
title_fullStr	Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer
title_full_unstemmed	Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer
title_sort	associations between dynamic-contrast enhanced mri and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a4ea0e25ffb74eb28c1f41285ff09534
work_keys_str_mv	AT hansjonasmeyer associationsbetweendynamiccontrastenhancedmriandtumorinfiltratinglymphocytesandtumorstromaratioinheadandnecksquamouscellcancer AT annekathrinhohn associationsbetweendynamiccontrastenhancedmriandtumorinfiltratinglymphocytesandtumorstromaratioinheadandnecksquamouscellcancer AT alexeysurov associationsbetweendynamiccontrastenhancedmriandtumorinfiltratinglymphocytesandtumorstromaratioinheadandnecksquamouscellcancer
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Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer

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