β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture

β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture

β-actin loss can affect gene expression and heterochromatin organization. Here the authors conduct a comprehensive genomic analysis of β-actin knockout mouse embryonic fibroblasts (MEFs) to investigate the impact of changes in β-actin levels on 3d genome architecture and chromatin remodeling activit...

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Autores principales: Syed Raza Mahmood, Xin Xie, Nadine Hosny El Said, Tomas Venit, Kristin C. Gunsalus, Piergiorgio Percipalle
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a4ea5e63186c4d90956c74c8cb8afbca
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spelling oai:doaj.org-article:a4ea5e63186c4d90956c74c8cb8afbca2021-12-02T16:38:26Zβ-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture10.1038/s41467-021-25596-22041-1723https://doaj.org/article/a4ea5e63186c4d90956c74c8cb8afbca2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25596-2https://doaj.org/toc/2041-1723β-actin loss can affect gene expression and heterochromatin organization. Here the authors conduct a comprehensive genomic analysis of β-actin knockout mouse embryonic fibroblasts (MEFs) to investigate the impact of changes in β-actin levels on 3d genome architecture and chromatin remodeling activities of BAF and polycomb proteins.Syed Raza MahmoodXin XieNadine Hosny El SaidTomas VenitKristin C. GunsalusPiergiorgio PercipalleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Syed Raza Mahmood
Xin Xie
Nadine Hosny El Said
Tomas Venit
Kristin C. Gunsalus
Piergiorgio Percipalle
β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture
description β-actin loss can affect gene expression and heterochromatin organization. Here the authors conduct a comprehensive genomic analysis of β-actin knockout mouse embryonic fibroblasts (MEFs) to investigate the impact of changes in β-actin levels on 3d genome architecture and chromatin remodeling activities of BAF and polycomb proteins.
format article
author Syed Raza Mahmood
Xin Xie
Nadine Hosny El Said
Tomas Venit
Kristin C. Gunsalus
Piergiorgio Percipalle
author_facet Syed Raza Mahmood
Xin Xie
Nadine Hosny El Said
Tomas Venit
Kristin C. Gunsalus
Piergiorgio Percipalle
author_sort Syed Raza Mahmood
title β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture
title_short β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture
title_full β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture
title_fullStr β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture
title_full_unstemmed β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture
title_sort β-actin dependent chromatin remodeling mediates compartment level changes in 3d genome architecture
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a4ea5e63186c4d90956c74c8cb8afbca
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AT xinxie bactindependentchromatinremodelingmediatescompartmentlevelchangesin3dgenomearchitecture
AT nadinehosnyelsaid bactindependentchromatinremodelingmediatescompartmentlevelchangesin3dgenomearchitecture
AT tomasvenit bactindependentchromatinremodelingmediatescompartmentlevelchangesin3dgenomearchitecture
AT kristincgunsalus bactindependentchromatinremodelingmediatescompartmentlevelchangesin3dgenomearchitecture
AT piergiorgiopercipalle bactindependentchromatinremodelingmediatescompartmentlevelchangesin3dgenomearchitecture
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