Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

Finger millet (<i>Eleusine coracana</i>) contains high levels of calcium and polyphenols, which have a variety of beneficial functions. We tested the hypothesis that finger millet ethanol extracts (FEs) have an antihypertensive effect in spontaneously hypertensive rats (SHRs). The study...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	angiotensin-converting enzyme (ACE) antioxidant hypertension finger millet renin Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a4f003f66ae640c18390863c5865e97b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a4f003f66ae640c18390863c5865e97b
record_format	dspace
spelling	oai:doaj.org-article:a4f003f66ae640c18390863c5865e97b2021-11-25T16:28:01ZFinger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats10.3390/antiox101117662076-3921https://doaj.org/article/a4f003f66ae640c18390863c5865e97b2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1766https://doaj.org/toc/2076-3921Finger millet (<i>Eleusine coracana</i>) contains high levels of calcium and polyphenols, which have a variety of beneficial functions. We tested the hypothesis that finger millet ethanol extracts (FEs) have an antihypertensive effect in spontaneously hypertensive rats (SHRs). The study groups were assigned as follows: (1) Wistar Kyoto rats (normal); (2) SHRs treated with saline (negative control); (3) SHRs treated with captopril 50 mg/kg bw (positive control); (4) SHRs treated with FE 250 mg/kg bw (FE250); and (5) SHRs treated with FE 500 mg/kg bw (FE500). FE supplementation improved the lipid profiles, including the triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, without deterioration in liver function. The thiobarbituric acid reactive substance concentration and superoxide dismutase activity significantly improved after the application of FE250 and FE500. Interestingly, FE250 and FE500 application dramatically reduced the systolic blood pressure. FE supplementation exhibited powerful control over the renin-angiotensin system by reducing the angiotensin-converting enzyme levels and renin mRNA expression in the kidney. Additionally, FE500 application ameliorated vascular remodeling, reversed the thickening media, and decreased the media thickness/lumen diameter ratio of the aorta. These results imply that FEs are a potent antihypertensive nutraceutical for regulating the renin–angiotensin system and simultaneously inhibiting oxidative stress.Se Yeong ParkEun Woo JeongYun Sun YangHyun-Joo KimGwang-woong GoHyeon Gyu LeeMDPI AGarticleangiotensin-converting enzyme (ACE)antioxidanthypertensionfinger milletreninTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1766, p 1766 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiotensin-converting enzyme (ACE) antioxidant hypertension finger millet renin Therapeutics. Pharmacology RM1-950
spellingShingle	angiotensin-converting enzyme (ACE) antioxidant hypertension finger millet renin Therapeutics. Pharmacology RM1-950 Se Yeong Park Eun Woo Jeong Yun Sun Yang Hyun-Joo Kim Gwang-woong Go Hyeon Gyu Lee Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats
description	Finger millet (<i>Eleusine coracana</i>) contains high levels of calcium and polyphenols, which have a variety of beneficial functions. We tested the hypothesis that finger millet ethanol extracts (FEs) have an antihypertensive effect in spontaneously hypertensive rats (SHRs). The study groups were assigned as follows: (1) Wistar Kyoto rats (normal); (2) SHRs treated with saline (negative control); (3) SHRs treated with captopril 50 mg/kg bw (positive control); (4) SHRs treated with FE 250 mg/kg bw (FE250); and (5) SHRs treated with FE 500 mg/kg bw (FE500). FE supplementation improved the lipid profiles, including the triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, without deterioration in liver function. The thiobarbituric acid reactive substance concentration and superoxide dismutase activity significantly improved after the application of FE250 and FE500. Interestingly, FE250 and FE500 application dramatically reduced the systolic blood pressure. FE supplementation exhibited powerful control over the renin-angiotensin system by reducing the angiotensin-converting enzyme levels and renin mRNA expression in the kidney. Additionally, FE500 application ameliorated vascular remodeling, reversed the thickening media, and decreased the media thickness/lumen diameter ratio of the aorta. These results imply that FEs are a potent antihypertensive nutraceutical for regulating the renin–angiotensin system and simultaneously inhibiting oxidative stress.
format	article
author	Se Yeong Park Eun Woo Jeong Yun Sun Yang Hyun-Joo Kim Gwang-woong Go Hyeon Gyu Lee
author_facet	Se Yeong Park Eun Woo Jeong Yun Sun Yang Hyun-Joo Kim Gwang-woong Go Hyeon Gyu Lee
author_sort	Se Yeong Park
title	Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats
title_short	Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats
title_full	Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats
title_fullStr	Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats
title_full_unstemmed	Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats
title_sort	finger millet ethanol extracts prevent hypertension by inhibiting the angiotensin-converting enzyme level and enhancing the antioxidant capacity in spontaneously hypertensive rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a4f003f66ae640c18390863c5865e97b
work_keys_str_mv	AT seyeongpark fingermilletethanolextractspreventhypertensionbyinhibitingtheangiotensinconvertingenzymelevelandenhancingtheantioxidantcapacityinspontaneouslyhypertensiverats AT eunwoojeong fingermilletethanolextractspreventhypertensionbyinhibitingtheangiotensinconvertingenzymelevelandenhancingtheantioxidantcapacityinspontaneouslyhypertensiverats AT yunsunyang fingermilletethanolextractspreventhypertensionbyinhibitingtheangiotensinconvertingenzymelevelandenhancingtheantioxidantcapacityinspontaneouslyhypertensiverats AT hyunjookim fingermilletethanolextractspreventhypertensionbyinhibitingtheangiotensinconvertingenzymelevelandenhancingtheantioxidantcapacityinspontaneouslyhypertensiverats AT gwangwoonggo fingermilletethanolextractspreventhypertensionbyinhibitingtheangiotensinconvertingenzymelevelandenhancingtheantioxidantcapacityinspontaneouslyhypertensiverats AT hyeongyulee fingermilletethanolextractspreventhypertensionbyinhibitingtheangiotensinconvertingenzymelevelandenhancingtheantioxidantcapacityinspontaneouslyhypertensiverats
_version_	1718413156874715136

Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

Ejemplares similares