Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study

Abstract We investigated body mass index (BMI) trajectories in the first 2 years of life in 1170 children from an Asian mother-offspring cohort in Singapore, and examined their predictors and associations with childhood cardio-metabolic risk measures at 5 years. Latent class growth mixture modelling...

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Autores principales:	Izzuddin M. Aris, Ling-Wei Chen, Mya Thway Tint, Wei Wei Pang, Shu E. Soh, Seang-Mei Saw, Lynette Pei-Chi Shek, Kok-Hian Tan, Peter D. Gluckman, Yap-Seng Chong, Fabian Yap, Keith M. Godfrey, Michael S. Kramer, Yung Seng Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4f07ca2bef94e68a5491e4d885cd39d
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spelling	oai:doaj.org-article:a4f07ca2bef94e68a5491e4d885cd39d2021-12-02T16:06:12ZBody mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study10.1038/s41598-017-09046-y2045-2322https://doaj.org/article/a4f07ca2bef94e68a5491e4d885cd39d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09046-yhttps://doaj.org/toc/2045-2322Abstract We investigated body mass index (BMI) trajectories in the first 2 years of life in 1170 children from an Asian mother-offspring cohort in Singapore, and examined their predictors and associations with childhood cardio-metabolic risk measures at 5 years. Latent class growth mixture modelling analyses were performed to identify distinct BMI z-score (BMIz) trajectories. Four trajectories were identified: 73.2%(n = 857) of the children showed a normal BMIz trajectory, 13.2%(n = 155) a stable low-BMIz trajectory, 8.6%(n = 100) a stable high-BMIz trajectory and 5.0%(n = 58) a rapid BMIz gain after 3 months trajectory. Predictors of the stable high-BMIz and rapid BMIz gain trajectories were pre-pregnancy BMI, gestational weight gain, Malay and Indian ethnicity, while predictors of stable low-BMIz trajectory were preterm delivery and Indian ethnicity. At 5 years, children with stable high-BMIz or rapid BMIz gain trajectories had increased waist-to-height ratios [B(95%CI) 0.02(0.01,0.03) and 0.03(0.02,0.04)], sum of skinfolds [0.42(0.19,0.65) and 0.70(0.36,1.03)SD units], fat-mass index [0.97(0.32,1.63)SD units] and risk of obesity [relative risk 3.22(1.73,6.05) and 2.56 (1.19,5.53)], but not higher blood pressure. BMIz trajectories were more predictive of adiposity at 5 years than was BMIz at 2 years. Our findings on BMIz trajectories in the first 2 years suggest important ethnic-specific differences and impacts on later metabolic outcomes.Izzuddin M. ArisLing-Wei ChenMya Thway TintWei Wei PangShu E. SohSeang-Mei SawLynette Pei-Chi ShekKok-Hian TanPeter D. GluckmanYap-Seng ChongFabian YapKeith M. GodfreyMichael S. KramerYung Seng LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Izzuddin M. Aris Ling-Wei Chen Mya Thway Tint Wei Wei Pang Shu E. Soh Seang-Mei Saw Lynette Pei-Chi Shek Kok-Hian Tan Peter D. Gluckman Yap-Seng Chong Fabian Yap Keith M. Godfrey Michael S. Kramer Yung Seng Lee Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study
description	Abstract We investigated body mass index (BMI) trajectories in the first 2 years of life in 1170 children from an Asian mother-offspring cohort in Singapore, and examined their predictors and associations with childhood cardio-metabolic risk measures at 5 years. Latent class growth mixture modelling analyses were performed to identify distinct BMI z-score (BMIz) trajectories. Four trajectories were identified: 73.2%(n = 857) of the children showed a normal BMIz trajectory, 13.2%(n = 155) a stable low-BMIz trajectory, 8.6%(n = 100) a stable high-BMIz trajectory and 5.0%(n = 58) a rapid BMIz gain after 3 months trajectory. Predictors of the stable high-BMIz and rapid BMIz gain trajectories were pre-pregnancy BMI, gestational weight gain, Malay and Indian ethnicity, while predictors of stable low-BMIz trajectory were preterm delivery and Indian ethnicity. At 5 years, children with stable high-BMIz or rapid BMIz gain trajectories had increased waist-to-height ratios [B(95%CI) 0.02(0.01,0.03) and 0.03(0.02,0.04)], sum of skinfolds [0.42(0.19,0.65) and 0.70(0.36,1.03)SD units], fat-mass index [0.97(0.32,1.63)SD units] and risk of obesity [relative risk 3.22(1.73,6.05) and 2.56 (1.19,5.53)], but not higher blood pressure. BMIz trajectories were more predictive of adiposity at 5 years than was BMIz at 2 years. Our findings on BMIz trajectories in the first 2 years suggest important ethnic-specific differences and impacts on later metabolic outcomes.
format	article
author	Izzuddin M. Aris Ling-Wei Chen Mya Thway Tint Wei Wei Pang Shu E. Soh Seang-Mei Saw Lynette Pei-Chi Shek Kok-Hian Tan Peter D. Gluckman Yap-Seng Chong Fabian Yap Keith M. Godfrey Michael S. Kramer Yung Seng Lee
author_facet	Izzuddin M. Aris Ling-Wei Chen Mya Thway Tint Wei Wei Pang Shu E. Soh Seang-Mei Saw Lynette Pei-Chi Shek Kok-Hian Tan Peter D. Gluckman Yap-Seng Chong Fabian Yap Keith M. Godfrey Michael S. Kramer Yung Seng Lee
author_sort	Izzuddin M. Aris
title	Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study
title_short	Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study
title_full	Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study
title_fullStr	Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study
title_full_unstemmed	Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study
title_sort	body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic asian cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a4f07ca2bef94e68a5491e4d885cd39d
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Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi-ethnic Asian cohort study

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