Identification of Recessive Lethal Alleles in the Diploid Genome of a <named-content content-type="genus-species">Candida albicans</named-content> Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact

Identification of Recessive Lethal Alleles in the Diploid Genome of a <named-content content-type="genus-species">Candida albicans</named-content> Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact

ABSTRACT The heterozygous diploid genome of Candida albicans is highly plastic, with frequent loss of heterozygosity (LOH) events. In the SC5314 laboratory strain, while LOH events are ubiquitous, a chromosome homozygosis bias is observed for certain chromosomes, whereby only one of the two homologs...

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Autores principales: Timea Marton, Adeline Feri, Pierre-Henri Commere, Corinne Maufrais, Christophe d’Enfert, Melanie Legrand
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Candida albicans
homologous recombination
loss of heterozygosity
major repeat sequences
recessive lethal alleles
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/a4f19e583b0040988497b79b9662e61f
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