Exon 9 of Vitamin D Receptor Association with Occult Hepatitis B Virus Infection

BACKGROUND AND OBJECTIVE: Immune system is unable to complete clearance of hepatitis B virus in occult hepatitis B infection (OBI). Some of immune response is defect against hepatitis B virus in these patients. Scientists believed the involvement of genetic and immunological factors in etiology of O...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M Kazemi Arababadi, AK Pourfathollah, A Jafarzadeh, GH.H Hassanshahi, ME Rezvani
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	hepatitis b vitamin d receptor polymorphism Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a4f2a4c6778c48ab8833a1a34ded0a99
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a4f2a4c6778c48ab8833a1a34ded0a99
record_format	dspace
spelling	oai:doaj.org-article:a4f2a4c6778c48ab8833a1a34ded0a992021-11-10T09:03:00ZExon 9 of Vitamin D Receptor Association with Occult Hepatitis B Virus Infection1561-41072251-7170https://doaj.org/article/a4f2a4c6778c48ab8833a1a34ded0a992009-10-01T00:00:00Zhttp://jbums.org/article-1-3253-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Immune system is unable to complete clearance of hepatitis B virus in occult hepatitis B infection (OBI). Some of immune response is defect against hepatitis B virus in these patients. Scientists believed the involvement of genetic and immunological factors in etiology of OBI. Due to the regulatory impact of vitamin D3 on immune system, study of vitamin D receptor (VDR) polymorphisms aid to better understanding of disease. Therefore, in this study we examined exon 9 polymorphisms of VDR in OBI patients.METHODS: In this experimental study, 3700 samples were examined for anti-HBc and HBsAg by ELISA. The HBsAg negative and anti-HBc positive samples were screened for HBV-DNA by PCR. OBI patients (57 cases) (HBsAg negative and anti-HBc positive, HBV-DNA positive) and 100 healthy controls (HBsAg negative and anti-HBc positive, HBV-DNA negative) were analyzed for exon 9 polymorphisms of VDR by PCR-RFLP techniques. FINDINGS: Our findings demonstrated that 57 cases had OBI among 3700 studied cases. Polymorphisms analysis showed that 3.5% (2 cases) of OBI patients and 18% (18 cases) of controls had T/T alleles in this region which the difference was statistically significant in patients and controls (p<0.049). There was not also a significant difference between OBI patients and controls regarding T/t and t/t alleles of this region of VDR. CONCLUSION: Regarding results of this study we can be concluded that the T/T allele in exon 9 of VDR may play key role in ability of immune system in clearance of HBV in OBI patients.M Kazemi ArababadiAK PourfathollahA JafarzadehGH.H HassanshahiME RezvaniBabol University of Medical Sciencesarticlehepatitis bvitamin d receptorpolymorphismMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 11, Iss 4, Pp 19-24 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	hepatitis b vitamin d receptor polymorphism Medicine R Medicine (General) R5-920
spellingShingle	hepatitis b vitamin d receptor polymorphism Medicine R Medicine (General) R5-920 M Kazemi Arababadi AK Pourfathollah A Jafarzadeh GH.H Hassanshahi ME Rezvani Exon 9 of Vitamin D Receptor Association with Occult Hepatitis B Virus Infection
description	BACKGROUND AND OBJECTIVE: Immune system is unable to complete clearance of hepatitis B virus in occult hepatitis B infection (OBI). Some of immune response is defect against hepatitis B virus in these patients. Scientists believed the involvement of genetic and immunological factors in etiology of OBI. Due to the regulatory impact of vitamin D3 on immune system, study of vitamin D receptor (VDR) polymorphisms aid to better understanding of disease. Therefore, in this study we examined exon 9 polymorphisms of VDR in OBI patients.METHODS: In this experimental study, 3700 samples were examined for anti-HBc and HBsAg by ELISA. The HBsAg negative and anti-HBc positive samples were screened for HBV-DNA by PCR. OBI patients (57 cases) (HBsAg negative and anti-HBc positive, HBV-DNA positive) and 100 healthy controls (HBsAg negative and anti-HBc positive, HBV-DNA negative) were analyzed for exon 9 polymorphisms of VDR by PCR-RFLP techniques. FINDINGS: Our findings demonstrated that 57 cases had OBI among 3700 studied cases. Polymorphisms analysis showed that 3.5% (2 cases) of OBI patients and 18% (18 cases) of controls had T/T alleles in this region which the difference was statistically significant in patients and controls (p<0.049). There was not also a significant difference between OBI patients and controls regarding T/t and t/t alleles of this region of VDR. CONCLUSION: Regarding results of this study we can be concluded that the T/T allele in exon 9 of VDR may play key role in ability of immune system in clearance of HBV in OBI patients.
format	article
author	M Kazemi Arababadi AK Pourfathollah A Jafarzadeh GH.H Hassanshahi ME Rezvani
author_facet	M Kazemi Arababadi AK Pourfathollah A Jafarzadeh GH.H Hassanshahi ME Rezvani
author_sort	M Kazemi Arababadi
title	Exon 9 of Vitamin D Receptor Association with Occult Hepatitis B Virus Infection
title_short	Exon 9 of Vitamin D Receptor Association with Occult Hepatitis B Virus Infection
title_full	Exon 9 of Vitamin D Receptor Association with Occult Hepatitis B Virus Infection
title_fullStr	Exon 9 of Vitamin D Receptor Association with Occult Hepatitis B Virus Infection
title_full_unstemmed	Exon 9 of Vitamin D Receptor Association with Occult Hepatitis B Virus Infection
title_sort	exon 9 of vitamin d receptor association with occult hepatitis b virus infection
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/a4f2a4c6778c48ab8833a1a34ded0a99
work_keys_str_mv	AT mkazemiarababadi exon9ofvitamindreceptorassociationwithocculthepatitisbvirusinfection AT akpourfathollah exon9ofvitamindreceptorassociationwithocculthepatitisbvirusinfection AT ajafarzadeh exon9ofvitamindreceptorassociationwithocculthepatitisbvirusinfection AT ghhhassanshahi exon9ofvitamindreceptorassociationwithocculthepatitisbvirusinfection AT merezvani exon9ofvitamindreceptorassociationwithocculthepatitisbvirusinfection
_version_	1718440315174518784

Exon 9 of Vitamin D Receptor Association with Occult Hepatitis B Virus Infection

Ejemplares similares