Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

Bo Wu,1,* Bing Wan,2,* Shu-Ting Lu,1 Kai Deng,3 Xiao-Qi Li,1 Bao-Lin Wu,1 Yu-Shuang Li,1 Ru-Fang Liao,1 Shi-Wen Huang,3 Hai-Bo Xu1,2 1Department of Radiology, Zhongnan Hospital of Wuhan University, 2Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science an...

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Autores principales:	Wu B, Wan B, Lu ST, Deng K, Li XQ, Wu BL, Li YS, Liao RF, Huang SW, Xu HB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	light-triggered near infrared light tumor-specific multimodal imaging photothermal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a4f8b8cef78a4be59c28c95a09f17ceb
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spelling	oai:doaj.org-article:a4f8b8cef78a4be59c28c95a09f17ceb2021-12-02T07:36:58ZNear-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy1178-2013https://doaj.org/article/a4f8b8cef78a4be59c28c95a09f17ceb2017-06-01T00:00:00Zhttps://www.dovepress.com/near-infrared-light-triggered-theranostics-for-tumor-specific-enhanced-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bo Wu,1,* Bing Wan,2,* Shu-Ting Lu,1 Kai Deng,3 Xiao-Qi Li,1 Bao-Lin Wu,1 Yu-Shuang Li,1 Ru-Fang Liao,1 Shi-Wen Huang,3 Hai-Bo Xu1,2 1Department of Radiology, Zhongnan Hospital of Wuhan University, 2Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 3Department of Chemistry, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Wuhan, People’s Republic of China *These authors contributed equally to this work Abstract: The major challenge in current clinic contrast agents (CAs) and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA between inner and outer of liposome, we developed “bomb-like” light-triggered CAs (LTCAs) for enhanced CT/MRI/FI multimodal imaging, which can improve the signal-to-noise ratio of tumor tissue specifically. IR820, Iohexol and Gd-chelates were firstly encapsulated into the thermal-sensitive nanocarrier with a high concentration. This will result in protection and fluorescence quenching. Then, the release of CAs was triggered by near-infrared (NIR) light laser irradiation, which will lead to fluorescence and MRI activation and enable imaging of inflammation. In vitro and in vivo experiments demonstrated that LTCAs with 808 nm laser irradiation have shorter T1 relaxation time in MRI and stronger intensity in FI compared to those without irradiation. Additionally, due to the high photothermal conversion efficiency of IR820, the injection of LTCAs was demonstrated to completely inhibit C6 tumor growth in nude mice up to 17 days after NIR laser irradiation. The results indicate that the LTCAs can serve as a promising platform for NIR-activated multimodal imaging and photothermal therapy. Keywords: light triggered, near-infrared light, tumor-specific, multimodal imaging, photothermal therapy, contrast agentsWu BWan BLu STDeng KLi XQWu BLLi YSLiao RFHuang SWXu HBDove Medical Pressarticlelight-triggerednear infrared lighttumor-specificmultimodal imagingphotothermal therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4467-4478 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	light-triggered near infrared light tumor-specific multimodal imaging photothermal therapy Medicine (General) R5-920
spellingShingle	light-triggered near infrared light tumor-specific multimodal imaging photothermal therapy Medicine (General) R5-920 Wu B Wan B Lu ST Deng K Li XQ Wu BL Li YS Liao RF Huang SW Xu HB Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy
description	Bo Wu,1,* Bing Wan,2,* Shu-Ting Lu,1 Kai Deng,3 Xiao-Qi Li,1 Bao-Lin Wu,1 Yu-Shuang Li,1 Ru-Fang Liao,1 Shi-Wen Huang,3 Hai-Bo Xu1,2 1Department of Radiology, Zhongnan Hospital of Wuhan University, 2Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 3Department of Chemistry, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Wuhan, People’s Republic of China *These authors contributed equally to this work Abstract: The major challenge in current clinic contrast agents (CAs) and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA between inner and outer of liposome, we developed “bomb-like” light-triggered CAs (LTCAs) for enhanced CT/MRI/FI multimodal imaging, which can improve the signal-to-noise ratio of tumor tissue specifically. IR820, Iohexol and Gd-chelates were firstly encapsulated into the thermal-sensitive nanocarrier with a high concentration. This will result in protection and fluorescence quenching. Then, the release of CAs was triggered by near-infrared (NIR) light laser irradiation, which will lead to fluorescence and MRI activation and enable imaging of inflammation. In vitro and in vivo experiments demonstrated that LTCAs with 808 nm laser irradiation have shorter T1 relaxation time in MRI and stronger intensity in FI compared to those without irradiation. Additionally, due to the high photothermal conversion efficiency of IR820, the injection of LTCAs was demonstrated to completely inhibit C6 tumor growth in nude mice up to 17 days after NIR laser irradiation. The results indicate that the LTCAs can serve as a promising platform for NIR-activated multimodal imaging and photothermal therapy. Keywords: light triggered, near-infrared light, tumor-specific, multimodal imaging, photothermal therapy, contrast agents
format	article
author	Wu B Wan B Lu ST Deng K Li XQ Wu BL Li YS Liao RF Huang SW Xu HB
author_facet	Wu B Wan B Lu ST Deng K Li XQ Wu BL Li YS Liao RF Huang SW Xu HB
author_sort	Wu B
title	Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy
title_short	Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy
title_full	Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy
title_fullStr	Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy
title_full_unstemmed	Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy
title_sort	near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a4f8b8cef78a4be59c28c95a09f17ceb
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_version_	1718399356063711232

Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

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