Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion

Abstract We aimed to investigate the increase in resistivity of the retinal artery in the branch retinal vein occlusion (BRVO)-affected area, and to visualize it. Thirty-two eyes of 32 patients with BRVO were measured by laser speckle flowgraphy (LSFG). The retinal artery and vein running to the BRV...

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Autores principales:	Ryo Tomita, Takeshi Iwase, Marie Fukami, Kensuke Goto, Eimei Ra, Hiroko Terasaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4fc832bebe7463d8ecf8ae4e9b2150f
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spelling	oai:doaj.org-article:a4fc832bebe7463d8ecf8ae4e9b2150f2021-12-02T18:37:11ZElevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion10.1038/s41598-021-99572-72045-2322https://doaj.org/article/a4fc832bebe7463d8ecf8ae4e9b2150f2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99572-7https://doaj.org/toc/2045-2322Abstract We aimed to investigate the increase in resistivity of the retinal artery in the branch retinal vein occlusion (BRVO)-affected area, and to visualize it. Thirty-two eyes of 32 patients with BRVO were measured by laser speckle flowgraphy (LSFG). The retinal artery and vein running to the BRVO-affected area and vertically symmetrical vessels in the unaffected area were examined. We applied the LSFG parameter beat strength over mean blur rate (BOM), calculated using a similar method to the pulsatility index used in Doppler flowmetry to evaluate resistivity of the vessels. Our results showed that the BOM map could clearly visualize the increase of resistivity in the retinal artery as a two-dimensional map. The BOM of the arteries in the affected area was significantly higher than that of the unaffected area (P = 0.001). Multiple regression analysis showed that the ratio of BOM in retinal arteries of the affected area to the unaffected was significantly associated with the extent of retinal hemorrhage (β = 0.447, P = 0.009). In conclusion, the index of resistivity of the retinal artery in the BRVO-affected area was higher and could be visualized in a two-dimensional map. These findings and techniques would contribute to elucidate the pathophysiology of BRVO.Ryo TomitaTakeshi IwaseMarie FukamiKensuke GotoEimei RaHiroko TerasakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryo Tomita Takeshi Iwase Marie Fukami Kensuke Goto Eimei Ra Hiroko Terasaki Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion
description	Abstract We aimed to investigate the increase in resistivity of the retinal artery in the branch retinal vein occlusion (BRVO)-affected area, and to visualize it. Thirty-two eyes of 32 patients with BRVO were measured by laser speckle flowgraphy (LSFG). The retinal artery and vein running to the BRVO-affected area and vertically symmetrical vessels in the unaffected area were examined. We applied the LSFG parameter beat strength over mean blur rate (BOM), calculated using a similar method to the pulsatility index used in Doppler flowmetry to evaluate resistivity of the vessels. Our results showed that the BOM map could clearly visualize the increase of resistivity in the retinal artery as a two-dimensional map. The BOM of the arteries in the affected area was significantly higher than that of the unaffected area (P = 0.001). Multiple regression analysis showed that the ratio of BOM in retinal arteries of the affected area to the unaffected was significantly associated with the extent of retinal hemorrhage (β = 0.447, P = 0.009). In conclusion, the index of resistivity of the retinal artery in the BRVO-affected area was higher and could be visualized in a two-dimensional map. These findings and techniques would contribute to elucidate the pathophysiology of BRVO.
format	article
author	Ryo Tomita Takeshi Iwase Marie Fukami Kensuke Goto Eimei Ra Hiroko Terasaki
author_facet	Ryo Tomita Takeshi Iwase Marie Fukami Kensuke Goto Eimei Ra Hiroko Terasaki
author_sort	Ryo Tomita
title	Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion
title_short	Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion
title_full	Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion
title_fullStr	Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion
title_full_unstemmed	Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion
title_sort	elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a4fc832bebe7463d8ecf8ae4e9b2150f
work_keys_str_mv	AT ryotomita elevatedretinalarteryvascularresistancedeterminedbynovelvisualizedtechniqueoflaserspeckleflowgraphyinbranchretinalveinocclusion AT takeshiiwase elevatedretinalarteryvascularresistancedeterminedbynovelvisualizedtechniqueoflaserspeckleflowgraphyinbranchretinalveinocclusion AT mariefukami elevatedretinalarteryvascularresistancedeterminedbynovelvisualizedtechniqueoflaserspeckleflowgraphyinbranchretinalveinocclusion AT kensukegoto elevatedretinalarteryvascularresistancedeterminedbynovelvisualizedtechniqueoflaserspeckleflowgraphyinbranchretinalveinocclusion AT eimeira elevatedretinalarteryvascularresistancedeterminedbynovelvisualizedtechniqueoflaserspeckleflowgraphyinbranchretinalveinocclusion AT hirokoterasaki elevatedretinalarteryvascularresistancedeterminedbynovelvisualizedtechniqueoflaserspeckleflowgraphyinbranchretinalveinocclusion
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Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion

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