Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge

Considering that the incidence of colorectal (CRC) and prostatic cancer (PC) increases with age, metachronous and synchronous tumors can often affect the same patient. Despite the importance of this subject for the diagnosis and management of oncologic patients, in medical literature the data are sc...

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Autores principales:	Sorin Dema, Andreea Bota, Sorina Maria Tăban, Adelina Gheju, Alis Liliana Carmen Dema, Alexei Croitor, Robert Alexandru Barna, Oana Popa, Răzvan Bardan, Alin-Adrian Cumpănaș
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/a4ff49e86b6747f988e948213a381c08
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spelling	oai:doaj.org-article:a4ff49e86b6747f988e948213a381c082021-11-12T11:03:34ZMultiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge1557-989110.1177/15579883211044881https://doaj.org/article/a4ff49e86b6747f988e948213a381c082021-09-01T00:00:00Zhttps://doi.org/10.1177/15579883211044881https://doaj.org/toc/1557-9891Considering that the incidence of colorectal (CRC) and prostatic cancer (PC) increases with age, metachronous and synchronous tumors can often affect the same patient. Despite the importance of this subject for the diagnosis and management of oncologic patients, in medical literature the data are scarce. The aim of the study was to evaluate the incidence and the characteristics of double/multiple primary malignant tumors (D/MPMTs) with colorectal and prostatic origin, in patients admitted to a reference hospital in West Romania. A 4-year retrospective observational study (2016–2019) was conducted by analyzing the medical records of all patients admitted in the hospital. Demographic and clinical data, as well as tumor-related parameters, were extracted. We identified 413 consecutive hospitalized patients with PC, and 21 (5%) of them also had a primary CRC. At the time of diagnosis, the mean age of the patients with PC was 71.2 ± 6 years, and 71.8 ± 10 years for patients with CRC. Synchronous PC and CRC tumors were identified in 3/21 cases and metachronous tumors in 18/21 cases. Prostate cancer was the first tumor to be diagnosed in 13/18 cases and CRC in 5/18 cases. The most frequent subtype of PC was acinar adenocarcinoma (90%) and for CRC cases, conventional adenocarcinoma (90%). Prostate and colorectal cancers tend to co-occur in a single patient. The diagnosis of one of these two types of tumors should imply the screening for the other one, because these patients require a multidisciplinary and personalized approach.Sorin DemaAndreea BotaSorina Maria TăbanAdelina GhejuAlis Liliana Carmen DemaAlexei CroitorRobert Alexandru BarnaOana PopaRăzvan BardanAlin-Adrian CumpănașSAGE PublishingarticleMedicineRENAmerican Journal of Men's Health, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Sorin Dema Andreea Bota Sorina Maria Tăban Adelina Gheju Alis Liliana Carmen Dema Alexei Croitor Robert Alexandru Barna Oana Popa Răzvan Bardan Alin-Adrian Cumpănaș Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge
description	Considering that the incidence of colorectal (CRC) and prostatic cancer (PC) increases with age, metachronous and synchronous tumors can often affect the same patient. Despite the importance of this subject for the diagnosis and management of oncologic patients, in medical literature the data are scarce. The aim of the study was to evaluate the incidence and the characteristics of double/multiple primary malignant tumors (D/MPMTs) with colorectal and prostatic origin, in patients admitted to a reference hospital in West Romania. A 4-year retrospective observational study (2016–2019) was conducted by analyzing the medical records of all patients admitted in the hospital. Demographic and clinical data, as well as tumor-related parameters, were extracted. We identified 413 consecutive hospitalized patients with PC, and 21 (5%) of them also had a primary CRC. At the time of diagnosis, the mean age of the patients with PC was 71.2 ± 6 years, and 71.8 ± 10 years for patients with CRC. Synchronous PC and CRC tumors were identified in 3/21 cases and metachronous tumors in 18/21 cases. Prostate cancer was the first tumor to be diagnosed in 13/18 cases and CRC in 5/18 cases. The most frequent subtype of PC was acinar adenocarcinoma (90%) and for CRC cases, conventional adenocarcinoma (90%). Prostate and colorectal cancers tend to co-occur in a single patient. The diagnosis of one of these two types of tumors should imply the screening for the other one, because these patients require a multidisciplinary and personalized approach.
format	article
author	Sorin Dema Andreea Bota Sorina Maria Tăban Adelina Gheju Alis Liliana Carmen Dema Alexei Croitor Robert Alexandru Barna Oana Popa Răzvan Bardan Alin-Adrian Cumpănaș
author_facet	Sorin Dema Andreea Bota Sorina Maria Tăban Adelina Gheju Alis Liliana Carmen Dema Alexei Croitor Robert Alexandru Barna Oana Popa Răzvan Bardan Alin-Adrian Cumpănaș
author_sort	Sorin Dema
title	Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge
title_short	Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge
title_full	Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge
title_fullStr	Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge
title_full_unstemmed	Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge
title_sort	multiple primary tumors originating from the prostate and colorectum a clinical-pathological and therapeutic challenge
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/a4ff49e86b6747f988e948213a381c08
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Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge

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