Kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process

In this study, the aim was to explore the effectiveness of the UV/H2O2 photolysis (UVP) process in terms of antimicrobial activity reduction and increasing the mean oxidation number of carbon (MONC) under the degradation of chloramphenicol (CHPL) drug. CHPL degradation kinetics and the effects of fo...

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Autores principales:	Ardhendu Sekhar Giri, Animes Kumar Golder, Sankar Chakma
Formato:	article
Lenguaje:	EN
Publicado:	IWA Publishing 2021
Materias:	electrophilic effect hydroxyl radical mean oxidation number photocatalysis toxicity Environmental technology. Sanitary engineering TD1-1066
Acceso en línea:	https://doaj.org/article/a4fff989c3204b1c93ca706a31a8b153
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spelling	oai:doaj.org-article:a4fff989c3204b1c93ca706a31a8b1532021-11-06T11:16:20ZKinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process0273-12231996-973210.2166/wst.2021.254https://doaj.org/article/a4fff989c3204b1c93ca706a31a8b1532021-08-01T00:00:00Zhttp://wst.iwaponline.com/content/84/3/524https://doaj.org/toc/0273-1223https://doaj.org/toc/1996-9732In this study, the aim was to explore the effectiveness of the UV/H2O2 photolysis (UVP) process in terms of antimicrobial activity reduction and increasing the mean oxidation number of carbon (MONC) under the degradation of chloramphenicol (CHPL) drug. CHPL degradation kinetics and the effects of foreign anions on CHPL degradation were explored in this study. The order of the inhibition effect was found as Cl− > NO3− > HCO3− due to their different in HO• radical scavenging capacity. A pseudo-first-order model for CHPL degradation was well established, and the rate constant (kobs) was 2.93 × 10−2 min−1 (R2 = 0.98) in UVP. Thirteen intermediate products were detected in MS-chromatogram and were identified through different proposed degradation pathways. The cleavage of the amide side chain in CHPL was more effective in CHPL degradation due to an electrophilic attacks by HO. radicals on it. The inactivation rates of E. coli were decreased due to the reduction of -NO2 group into -NH2 functional group in CHPL that leads to the production of low toxic compounds on CHPL degradation. HIGHLIGHTS Degradation of chloramphenicol drug occurred by UV-irradiation and hydrogen peroxide together.; HO• radical formed in the presence of H2O2 could effectively contribute to the degradation of CHPL.; MONC was increased with increasing the formation of daughter fragments.; Reduction of CHPL decreases the antimicrobial activity.; Dynamics of drug cleavage follows pseudo-first-order kinetics.;Ardhendu Sekhar GiriAnimes Kumar GolderSankar ChakmaIWA Publishingarticleelectrophilic effecthydroxyl radicalmean oxidation numberphotocatalysistoxicityEnvironmental technology. Sanitary engineeringTD1-1066ENWater Science and Technology, Vol 84, Iss 3, Pp 524-537 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	electrophilic effect hydroxyl radical mean oxidation number photocatalysis toxicity Environmental technology. Sanitary engineering TD1-1066
spellingShingle	electrophilic effect hydroxyl radical mean oxidation number photocatalysis toxicity Environmental technology. Sanitary engineering TD1-1066 Ardhendu Sekhar Giri Animes Kumar Golder Sankar Chakma Kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process
description	In this study, the aim was to explore the effectiveness of the UV/H2O2 photolysis (UVP) process in terms of antimicrobial activity reduction and increasing the mean oxidation number of carbon (MONC) under the degradation of chloramphenicol (CHPL) drug. CHPL degradation kinetics and the effects of foreign anions on CHPL degradation were explored in this study. The order of the inhibition effect was found as Cl− > NO3− > HCO3− due to their different in HO• radical scavenging capacity. A pseudo-first-order model for CHPL degradation was well established, and the rate constant (kobs) was 2.93 × 10−2 min−1 (R2 = 0.98) in UVP. Thirteen intermediate products were detected in MS-chromatogram and were identified through different proposed degradation pathways. The cleavage of the amide side chain in CHPL was more effective in CHPL degradation due to an electrophilic attacks by HO. radicals on it. The inactivation rates of E. coli were decreased due to the reduction of -NO2 group into -NH2 functional group in CHPL that leads to the production of low toxic compounds on CHPL degradation. HIGHLIGHTS Degradation of chloramphenicol drug occurred by UV-irradiation and hydrogen peroxide together.; HO• radical formed in the presence of H2O2 could effectively contribute to the degradation of CHPL.; MONC was increased with increasing the formation of daughter fragments.; Reduction of CHPL decreases the antimicrobial activity.; Dynamics of drug cleavage follows pseudo-first-order kinetics.;
format	article
author	Ardhendu Sekhar Giri Animes Kumar Golder Sankar Chakma
author_facet	Ardhendu Sekhar Giri Animes Kumar Golder Sankar Chakma
author_sort	Ardhendu Sekhar Giri
title	Kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process
title_short	Kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process
title_full	Kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process
title_fullStr	Kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process
title_full_unstemmed	Kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process
title_sort	kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by uv/h2o2 process
publisher	IWA Publishing
publishDate	2021
url	https://doaj.org/article/a4fff989c3204b1c93ca706a31a8b153
work_keys_str_mv	AT ardhendusekhargiri kineticsdegradationmechanismsandantibioticactivityreductionofchloramphenicolinaqueoussolutionbyuvh2o2process AT animeskumargolder kineticsdegradationmechanismsandantibioticactivityreductionofchloramphenicolinaqueoussolutionbyuvh2o2process AT sankarchakma kineticsdegradationmechanismsandantibioticactivityreductionofchloramphenicolinaqueoussolutionbyuvh2o2process
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Kinetics, degradation mechanisms and antibiotic activity reduction of chloramphenicol in aqueous solution by UV/H2O2 process

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