Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study

Background and Purpose: The risk factors for progression in vestibular schwannomas (VSs) after incomplete resection (IR) remain to be elucidated. The purpose of this study was to investigate the risk factors for progression in remnant VSs after surgery.Methods: From January 2009 to January 2018, 140...

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Autores principales:	Jiuhong Li, Xueyun Deng, Daibo Ke, Jian Cheng, Si Zhang, Xuhui Hui
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	vestibular schwannoma incomplete resection progression risk factor internal auditory canal tumor size Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a50235eba6a2456a86b98fcc72491a81
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spelling	oai:doaj.org-article:a50235eba6a2456a86b98fcc72491a812021-12-01T04:11:57ZRisk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study1664-229510.3389/fneur.2021.778590https://doaj.org/article/a50235eba6a2456a86b98fcc72491a812021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.778590/fullhttps://doaj.org/toc/1664-2295Background and Purpose: The risk factors for progression in vestibular schwannomas (VSs) after incomplete resection (IR) remain to be elucidated. The purpose of this study was to investigate the risk factors for progression in remnant VSs after surgery.Methods: From January 2009 to January 2018, 140 consecutive patients who underwent IR of VSs via suboccipital retrosigmoid approach in our institution were retrospectively analyzed. During follow-up, if progression was detected, the patient was classified into Progressive Group (PG); if the residual tumor was stable or shrank, the patient was classified into Stable Group (SG). Univariate analysis and multivariate analysis were used to evaluate the risk factors for progression after IR of VSs.Results: After a mean follow-up of 80.4 months (range, 24–134 months), 35 (25.0%) patients (PG) had a progression, and no progression was detected in 105 (75.0%) patients (SG). The average tumor size was 36.5 ± 8.9 mm in PG and 31.0 ± 9.8 mm in SG, respectively. The residual tumor volume was 304.6 ± 443.3 mm3 in PG and 75.9 ± 60.0 mm3 in SG, respectively. Univariate analysis showed that preoperative tumor size, residual tumor volume, and irregular internal auditory canal (IAC) expansion were significantly different between the two groups, whereas gender, age, cystic component, or Ki-67 labeling index (LI) did not differ significantly between the two groups. Multivariate analysis showed residual tumor volume was the independent risk factor for progression.Conclusions: VSs that underwent IR with larger preoperative size, greater residual tumor volume, or irregular IAC expansion may have a higher progression rate. Strict follow-up with shorter interval in these patients to detect early progression is necessary.Jiuhong LiXueyun DengDaibo KeJian ChengSi ZhangXuhui HuiFrontiers Media S.A.articlevestibular schwannomaincomplete resectionprogressionrisk factorinternal auditory canaltumor sizeNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vestibular schwannoma incomplete resection progression risk factor internal auditory canal tumor size Neurology. Diseases of the nervous system RC346-429
spellingShingle	vestibular schwannoma incomplete resection progression risk factor internal auditory canal tumor size Neurology. Diseases of the nervous system RC346-429 Jiuhong Li Xueyun Deng Daibo Ke Jian Cheng Si Zhang Xuhui Hui Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
description	Background and Purpose: The risk factors for progression in vestibular schwannomas (VSs) after incomplete resection (IR) remain to be elucidated. The purpose of this study was to investigate the risk factors for progression in remnant VSs after surgery.Methods: From January 2009 to January 2018, 140 consecutive patients who underwent IR of VSs via suboccipital retrosigmoid approach in our institution were retrospectively analyzed. During follow-up, if progression was detected, the patient was classified into Progressive Group (PG); if the residual tumor was stable or shrank, the patient was classified into Stable Group (SG). Univariate analysis and multivariate analysis were used to evaluate the risk factors for progression after IR of VSs.Results: After a mean follow-up of 80.4 months (range, 24–134 months), 35 (25.0%) patients (PG) had a progression, and no progression was detected in 105 (75.0%) patients (SG). The average tumor size was 36.5 ± 8.9 mm in PG and 31.0 ± 9.8 mm in SG, respectively. The residual tumor volume was 304.6 ± 443.3 mm3 in PG and 75.9 ± 60.0 mm3 in SG, respectively. Univariate analysis showed that preoperative tumor size, residual tumor volume, and irregular internal auditory canal (IAC) expansion were significantly different between the two groups, whereas gender, age, cystic component, or Ki-67 labeling index (LI) did not differ significantly between the two groups. Multivariate analysis showed residual tumor volume was the independent risk factor for progression.Conclusions: VSs that underwent IR with larger preoperative size, greater residual tumor volume, or irregular IAC expansion may have a higher progression rate. Strict follow-up with shorter interval in these patients to detect early progression is necessary.
format	article
author	Jiuhong Li Xueyun Deng Daibo Ke Jian Cheng Si Zhang Xuhui Hui
author_facet	Jiuhong Li Xueyun Deng Daibo Ke Jian Cheng Si Zhang Xuhui Hui
author_sort	Jiuhong Li
title	Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_short	Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_full	Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_fullStr	Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_full_unstemmed	Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study
title_sort	risk factors for progression in vestibular schwannomas after incomplete resection: a single center retrospective study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a50235eba6a2456a86b98fcc72491a81
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Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study

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