Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity
Virulent pathogens generally induce a stronger mucosal immunity than avirulent strains, but whether the associated inflammation is necessary for this is unclear. Here, using auxotrophic Salmonella enterica, the authors show that virulence factor function determines induction of protective IgA.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a504641b48c641b380390cd26e0b3e02 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a504641b48c641b380390cd26e0b3e02 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a504641b48c641b380390cd26e0b3e022021-12-02T15:34:36ZUncoupling of invasive bacterial mucosal immunogenicity from pathogenicity10.1038/s41467-020-15891-92041-1723https://doaj.org/article/a504641b48c641b380390cd26e0b3e022020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15891-9https://doaj.org/toc/2041-1723Virulent pathogens generally induce a stronger mucosal immunity than avirulent strains, but whether the associated inflammation is necessary for this is unclear. Here, using auxotrophic Salmonella enterica, the authors show that virulence factor function determines induction of protective IgA.Simona P. PfisterOlivier P. SchärenLuca BeldiAndrea PrintzMatheus D. NotterMohana MukherjeeHai LiJulien P. LimenitakisJoel P. WerrenDisha TandonMiguelangel CuencaStefanie HagemannStephanie S. UsterMiguel A. TerrazosMercedes Gomez de AgüeroChristian M. SchürchFernanda M. CoelhoRoy CurtissEmma SlackMaria L. BalmerSiegfried HapfelmeierNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Simona P. Pfister Olivier P. Schären Luca Beldi Andrea Printz Matheus D. Notter Mohana Mukherjee Hai Li Julien P. Limenitakis Joel P. Werren Disha Tandon Miguelangel Cuenca Stefanie Hagemann Stephanie S. Uster Miguel A. Terrazos Mercedes Gomez de Agüero Christian M. Schürch Fernanda M. Coelho Roy Curtiss Emma Slack Maria L. Balmer Siegfried Hapfelmeier Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity |
| description |
Virulent pathogens generally induce a stronger mucosal immunity than avirulent strains, but whether the associated inflammation is necessary for this is unclear. Here, using auxotrophic Salmonella enterica, the authors show that virulence factor function determines induction of protective IgA. |
| format |
article |
| author |
Simona P. Pfister Olivier P. Schären Luca Beldi Andrea Printz Matheus D. Notter Mohana Mukherjee Hai Li Julien P. Limenitakis Joel P. Werren Disha Tandon Miguelangel Cuenca Stefanie Hagemann Stephanie S. Uster Miguel A. Terrazos Mercedes Gomez de Agüero Christian M. Schürch Fernanda M. Coelho Roy Curtiss Emma Slack Maria L. Balmer Siegfried Hapfelmeier |
| author_facet |
Simona P. Pfister Olivier P. Schären Luca Beldi Andrea Printz Matheus D. Notter Mohana Mukherjee Hai Li Julien P. Limenitakis Joel P. Werren Disha Tandon Miguelangel Cuenca Stefanie Hagemann Stephanie S. Uster Miguel A. Terrazos Mercedes Gomez de Agüero Christian M. Schürch Fernanda M. Coelho Roy Curtiss Emma Slack Maria L. Balmer Siegfried Hapfelmeier |
| author_sort |
Simona P. Pfister |
| title |
Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity |
| title_short |
Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity |
| title_full |
Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity |
| title_fullStr |
Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity |
| title_full_unstemmed |
Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity |
| title_sort |
uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/a504641b48c641b380390cd26e0b3e02 |
| work_keys_str_mv |
AT simonappfister uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT olivierpscharen uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT lucabeldi uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT andreaprintz uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT matheusdnotter uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT mohanamukherjee uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT haili uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT julienplimenitakis uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT joelpwerren uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT dishatandon uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT miguelangelcuenca uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT stefaniehagemann uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT stephaniesuster uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT miguelaterrazos uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT mercedesgomezdeaguero uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT christianmschurch uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT fernandamcoelho uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT roycurtiss uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT emmaslack uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT marialbalmer uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity AT siegfriedhapfelmeier uncouplingofinvasivebacterialmucosalimmunogenicityfrompathogenicity |
| _version_ |
1718386797105381376 |