Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds

Copper is an important transition metal cofactor in plant metabolism, which enables diverse biocatalysis in aerobic environments. Multiple classes of plant metalloenzymes evolved and underwent genetic expansions during the evolution of terrestrial plants and, to date, several representatives of thes...

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Autores principales:	Lisa S. Mydy, Desnor N. Chigumba, Roland D. Kersten
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	copper enzyme plant metabolism biosynthesis copper biocatalysis Plant culture SB1-1110
Acceso en línea:	https://doaj.org/article/a508360e08a94cfa84e270c833693dee
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spelling	oai:doaj.org-article:a508360e08a94cfa84e270c833693dee2021-12-02T01:08:59ZPlant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds1664-462X10.3389/fpls.2021.692108https://doaj.org/article/a508360e08a94cfa84e270c833693dee2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpls.2021.692108/fullhttps://doaj.org/toc/1664-462XCopper is an important transition metal cofactor in plant metabolism, which enables diverse biocatalysis in aerobic environments. Multiple classes of plant metalloenzymes evolved and underwent genetic expansions during the evolution of terrestrial plants and, to date, several representatives of these copper enzyme classes have characterized mechanisms. In this review, we give an updated overview of chemistry, structure, mechanism, function and phylogenetic distribution of plant copper metalloenzymes with an emphasis on biosynthesis of aromatic compounds such as phenylpropanoids (lignin, lignan, flavonoids) and cyclic peptides with macrocyclizations via aromatic amino acids. We also review a recent addition to plant copper enzymology in a copper-dependent peptide cyclase called the BURP domain. Given growing plant genetic resources, a large pool of copper biocatalysts remains to be characterized from plants as plant genomes contain on average more than 70 copper enzyme genes. A major challenge in characterization of copper biocatalysts from plant genomes is the identification of endogenous substrates and catalyzed reactions. We highlight some recent and future trends in filling these knowledge gaps in plant metabolism and the potential for genomic discovery of copper-based enzymology from plants.Lisa S. MydyDesnor N. ChigumbaRoland D. KerstenFrontiers Media S.A.articlecopper enzymeplant metabolismbiosynthesiscopperbiocatalysisPlant cultureSB1-1110ENFrontiers in Plant Science, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	copper enzyme plant metabolism biosynthesis copper biocatalysis Plant culture SB1-1110
spellingShingle	copper enzyme plant metabolism biosynthesis copper biocatalysis Plant culture SB1-1110 Lisa S. Mydy Desnor N. Chigumba Roland D. Kersten Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds
description	Copper is an important transition metal cofactor in plant metabolism, which enables diverse biocatalysis in aerobic environments. Multiple classes of plant metalloenzymes evolved and underwent genetic expansions during the evolution of terrestrial plants and, to date, several representatives of these copper enzyme classes have characterized mechanisms. In this review, we give an updated overview of chemistry, structure, mechanism, function and phylogenetic distribution of plant copper metalloenzymes with an emphasis on biosynthesis of aromatic compounds such as phenylpropanoids (lignin, lignan, flavonoids) and cyclic peptides with macrocyclizations via aromatic amino acids. We also review a recent addition to plant copper enzymology in a copper-dependent peptide cyclase called the BURP domain. Given growing plant genetic resources, a large pool of copper biocatalysts remains to be characterized from plants as plant genomes contain on average more than 70 copper enzyme genes. A major challenge in characterization of copper biocatalysts from plant genomes is the identification of endogenous substrates and catalyzed reactions. We highlight some recent and future trends in filling these knowledge gaps in plant metabolism and the potential for genomic discovery of copper-based enzymology from plants.
format	article
author	Lisa S. Mydy Desnor N. Chigumba Roland D. Kersten
author_facet	Lisa S. Mydy Desnor N. Chigumba Roland D. Kersten
author_sort	Lisa S. Mydy
title	Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds
title_short	Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds
title_full	Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds
title_fullStr	Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds
title_full_unstemmed	Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds
title_sort	plant copper metalloenzymes as prospects for new metabolism involving aromatic compounds
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a508360e08a94cfa84e270c833693dee
work_keys_str_mv	AT lisasmydy plantcoppermetalloenzymesasprospectsfornewmetabolisminvolvingaromaticcompounds AT desnornchigumba plantcoppermetalloenzymesasprospectsfornewmetabolisminvolvingaromaticcompounds AT rolanddkersten plantcoppermetalloenzymesasprospectsfornewmetabolisminvolvingaromaticcompounds
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Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds

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