Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice

Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice

Dysfunction of mGluR5 has been implicated in Fragile X syndrome. Here, using a single-molecule tracking technique, the authors found an increased lateral mobility of mGluR5 at the synaptic site in Fmr1 KO hippocampal neurons, leading to abnormal NMDAR-mediated synaptic plasticity and cognitive defic...

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Autores principales: Elisabetta Aloisi, Katy Le Corf, Julien Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, Matthias Georg Haberl, Lara Costa, Ryuichi Shigemoto, Anke Tappe-Theodor, Filippo Drago, Pier Vincenzo Piazza, Christophe Mulle, Laurent Groc, Lucia Ciranna, Maria Vincenza Catania, Andreas Frick
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a5099cbf5e534deea4c2a121546338d3
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spelling oai:doaj.org-article:a5099cbf5e534deea4c2a121546338d32021-12-02T15:38:41ZAltered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice10.1038/s41467-017-01191-22041-1723https://doaj.org/article/a5099cbf5e534deea4c2a121546338d32017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01191-2https://doaj.org/toc/2041-1723Dysfunction of mGluR5 has been implicated in Fragile X syndrome. Here, using a single-molecule tracking technique, the authors found an increased lateral mobility of mGluR5 at the synaptic site in Fmr1 KO hippocampal neurons, leading to abnormal NMDAR-mediated synaptic plasticity and cognitive deficits.Elisabetta AloisiKaty Le CorfJulien DupuisPei ZhangMelanie GingerVirginie LabrousseMichela SpatuzzaMatthias Georg HaberlLara CostaRyuichi ShigemotoAnke Tappe-TheodorFilippo DragoPier Vincenzo PiazzaChristophe MulleLaurent GrocLucia CirannaMaria Vincenza CataniaAndreas FrickNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elisabetta Aloisi
Katy Le Corf
Julien Dupuis
Pei Zhang
Melanie Ginger
Virginie Labrousse
Michela Spatuzza
Matthias Georg Haberl
Lara Costa
Ryuichi Shigemoto
Anke Tappe-Theodor
Filippo Drago
Pier Vincenzo Piazza
Christophe Mulle
Laurent Groc
Lucia Ciranna
Maria Vincenza Catania
Andreas Frick
Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice
description Dysfunction of mGluR5 has been implicated in Fragile X syndrome. Here, using a single-molecule tracking technique, the authors found an increased lateral mobility of mGluR5 at the synaptic site in Fmr1 KO hippocampal neurons, leading to abnormal NMDAR-mediated synaptic plasticity and cognitive deficits.
format article
author Elisabetta Aloisi
Katy Le Corf
Julien Dupuis
Pei Zhang
Melanie Ginger
Virginie Labrousse
Michela Spatuzza
Matthias Georg Haberl
Lara Costa
Ryuichi Shigemoto
Anke Tappe-Theodor
Filippo Drago
Pier Vincenzo Piazza
Christophe Mulle
Laurent Groc
Lucia Ciranna
Maria Vincenza Catania
Andreas Frick
author_facet Elisabetta Aloisi
Katy Le Corf
Julien Dupuis
Pei Zhang
Melanie Ginger
Virginie Labrousse
Michela Spatuzza
Matthias Georg Haberl
Lara Costa
Ryuichi Shigemoto
Anke Tappe-Theodor
Filippo Drago
Pier Vincenzo Piazza
Christophe Mulle
Laurent Groc
Lucia Ciranna
Maria Vincenza Catania
Andreas Frick
author_sort Elisabetta Aloisi
title Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice
title_short Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice
title_full Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice
title_fullStr Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice
title_full_unstemmed Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice
title_sort altered surface mglur5 dynamics provoke synaptic nmdar dysfunction and cognitive defects in fmr1 knockout mice
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a5099cbf5e534deea4c2a121546338d3
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