Homomeric GluA2(R) AMPA receptors can conduct when desensitized

AMPA-type glutamate receptors, which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization, causing a progressive current decline in the continued presence of agonist. Here authors show that homomeric Q/R edited AMPARs still allow ions to flow when the receptors ar...

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Autores principales:	Ian D. Coombs, David Soto, Thomas P. McGee, Matthew G. Gold, Mark Farrant, Stuart G. Cull-Candy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a50e120ec8be4c268b59eed05b410716
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spelling	oai:doaj.org-article:a50e120ec8be4c268b59eed05b4107162021-12-02T17:31:22ZHomomeric GluA2(R) AMPA receptors can conduct when desensitized10.1038/s41467-019-12280-92041-1723https://doaj.org/article/a50e120ec8be4c268b59eed05b4107162019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12280-9https://doaj.org/toc/2041-1723AMPA-type glutamate receptors, which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization, causing a progressive current decline in the continued presence of agonist. Here authors show that homomeric Q/R edited AMPARs still allow ions to flow when the receptors are desensitized.Ian D. CoombsDavid SotoThomas P. McGeeMatthew G. GoldMark FarrantStuart G. Cull-CandyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ian D. Coombs David Soto Thomas P. McGee Matthew G. Gold Mark Farrant Stuart G. Cull-Candy Homomeric GluA2(R) AMPA receptors can conduct when desensitized
description	AMPA-type glutamate receptors, which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization, causing a progressive current decline in the continued presence of agonist. Here authors show that homomeric Q/R edited AMPARs still allow ions to flow when the receptors are desensitized.
format	article
author	Ian D. Coombs David Soto Thomas P. McGee Matthew G. Gold Mark Farrant Stuart G. Cull-Candy
author_facet	Ian D. Coombs David Soto Thomas P. McGee Matthew G. Gold Mark Farrant Stuart G. Cull-Candy
author_sort	Ian D. Coombs
title	Homomeric GluA2(R) AMPA receptors can conduct when desensitized
title_short	Homomeric GluA2(R) AMPA receptors can conduct when desensitized
title_full	Homomeric GluA2(R) AMPA receptors can conduct when desensitized
title_fullStr	Homomeric GluA2(R) AMPA receptors can conduct when desensitized
title_full_unstemmed	Homomeric GluA2(R) AMPA receptors can conduct when desensitized
title_sort	homomeric glua2(r) ampa receptors can conduct when desensitized
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a50e120ec8be4c268b59eed05b410716
work_keys_str_mv	AT iandcoombs homomericglua2rampareceptorscanconductwhendesensitized AT davidsoto homomericglua2rampareceptorscanconductwhendesensitized AT thomaspmcgee homomericglua2rampareceptorscanconductwhendesensitized AT matthewggold homomericglua2rampareceptorscanconductwhendesensitized AT markfarrant homomericglua2rampareceptorscanconductwhendesensitized AT stuartgcullcandy homomericglua2rampareceptorscanconductwhendesensitized
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Homomeric GluA2(R) AMPA receptors can conduct when desensitized

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