Relationship between chronic kidney disease and metabolic syndrome: current perspectives

Khaled Nashar,1 Brent M Egan2 1Division of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA, USA; 2Care Coordination Institute and Greenville Health System, Greenville, SC, USA Abstract: Both metabolic syndrome (MetS) and chronic kidney disease (CKD) are increasing in incide...

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Autores principales:	Nashar K, Egan BM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/a50f27888ce74f4b8b83734542ac2a61
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spelling	oai:doaj.org-article:a50f27888ce74f4b8b83734542ac2a612021-12-02T03:47:32ZRelationship between chronic kidney disease and metabolic syndrome: current perspectives1178-7007https://doaj.org/article/a50f27888ce74f4b8b83734542ac2a612014-09-01T00:00:00Zhttp://www.dovepress.com/relationship-between-chronic-kidney-disease-and-metabolic-syndrome-cur-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007 Khaled Nashar,1 Brent M Egan2 1Division of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA, USA; 2Care Coordination Institute and Greenville Health System, Greenville, SC, USA Abstract: Both metabolic syndrome (MetS) and chronic kidney disease (CKD) are increasing in incidence and lead to significant cardiovascular morbidity and mortality. The relationship between these two entities is complex. Individual components of the MetS are known risk factors for incident kidney disease, but it is not clear how the clustering of these components is linked to the development and progression of kidney disease. Cross-sectional studies show an association of the MetS and prevalent CKD; however, one cannot draw conclusions as to which came first – the MetS or the kidney disease. Observational studies suggest a relationship between MetS and incident CKD, but they also demonstrate the development of MetS in patients with established CKD. These observations suggest a bidirectional relationship. A better understanding of the relationship between components of the MetS and whether and how these components contribute to progression of CKD and incident cardiovascular disease could inform more effective prevention strategies. Keywords: obesity, insulin resistance, hypertension, oxdative stress, inflammation, adipokines Nashar KEgan BMDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 421-435 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Nashar K Egan BM Relationship between chronic kidney disease and metabolic syndrome: current perspectives
description	Khaled Nashar,1 Brent M Egan2 1Division of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA, USA; 2Care Coordination Institute and Greenville Health System, Greenville, SC, USA Abstract: Both metabolic syndrome (MetS) and chronic kidney disease (CKD) are increasing in incidence and lead to significant cardiovascular morbidity and mortality. The relationship between these two entities is complex. Individual components of the MetS are known risk factors for incident kidney disease, but it is not clear how the clustering of these components is linked to the development and progression of kidney disease. Cross-sectional studies show an association of the MetS and prevalent CKD; however, one cannot draw conclusions as to which came first – the MetS or the kidney disease. Observational studies suggest a relationship between MetS and incident CKD, but they also demonstrate the development of MetS in patients with established CKD. These observations suggest a bidirectional relationship. A better understanding of the relationship between components of the MetS and whether and how these components contribute to progression of CKD and incident cardiovascular disease could inform more effective prevention strategies. Keywords: obesity, insulin resistance, hypertension, oxdative stress, inflammation, adipokines
format	article
author	Nashar K Egan BM
author_facet	Nashar K Egan BM
author_sort	Nashar K
title	Relationship between chronic kidney disease and metabolic syndrome: current perspectives
title_short	Relationship between chronic kidney disease and metabolic syndrome: current perspectives
title_full	Relationship between chronic kidney disease and metabolic syndrome: current perspectives
title_fullStr	Relationship between chronic kidney disease and metabolic syndrome: current perspectives
title_full_unstemmed	Relationship between chronic kidney disease and metabolic syndrome: current perspectives
title_sort	relationship between chronic kidney disease and metabolic syndrome: current perspectives
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/a50f27888ce74f4b8b83734542ac2a61
work_keys_str_mv	AT nashark relationshipbetweenchronickidneydiseaseandmetabolicsyndromecurrentperspectives AT eganbm relationshipbetweenchronickidneydiseaseandmetabolicsyndromecurrentperspectives
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Relationship between chronic kidney disease and metabolic syndrome: current perspectives

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