ORIGINS OF ALLOGENEIC RESPONSE

Abstract. The MHC molecules are the strongest transplantational antigens determining direct intraction with 95-98% of T cell clones activating in response to allograft. Interaction with MHC molecules is critically important for positive selection of thymocytes and subsequent acquiring the capability...

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Autor principal:	D. B. Kazanskii
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	mhc molecules tymus alloreactivity tolerance graft Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a513d7f4560547e690b9884dfba5aaae
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spelling	oai:doaj.org-article:a513d7f4560547e690b9884dfba5aaae2021-11-18T08:03:42ZORIGINS OF ALLOGENEIC RESPONSE1563-06252313-741X10.15789/1563-0625-2005-5-6-477-488https://doaj.org/article/a513d7f4560547e690b9884dfba5aaae2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/585https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The MHC molecules are the strongest transplantational antigens determining direct intraction with 95-98% of T cell clones activating in response to allograft. Interaction with MHC molecules is critically important for positive selection of thymocytes and subsequent acquiring the capability to recognize "self" and "foreign". In this light, alloreactivity was recognized as cross-reactivity with foreign MHC that appeared as result of repertoire selection on "self" MHC molecules. The T lymphocyte repertoire is formed in the thymus as a result of random rearrangement of germinal sequences of TCR gene fragments and other processes that bring about the diversity of TCRs. As shown by D. Raulet and co-workers, repertoire of T lymphocytes artificially formed at the absence of selection processes, is inherently capable of reacting with different allelic forms of MHC molecules. In contrast to germinal sequences of TCR fragments, the MHC molecules are characterized by a significant interspecies polymorphism. So, negative and positive selection are aimed at the adaptation of repertoire to the specific MHC-environment of certain individual. The overall goal of adaptation is the elimination of autoreactive clones and sparing a broad spectrum of specificity to potential pathogens. Recent results have shown that positive selection in thymus was result of degenerative recognition of endog- enous MHC/peptide complexes. In contrast, central, telerance to "self" is formed as result of high affinity specific interaction with self MHC/peptide complexes. From this viewpoint the negative selection in the thymus can be considered as a life-long allogenic reaction of repertoire to self MHC molecules; the responses of the mature T cell repertoire to individual antigenic peptides can be considered as cross-reactions of T cells reactive to foreign transplantational antigens. I believe that this interpretation can unveil the origins and biological mean-ingfulness of allogenic reactions.D. B. KazanskiiSPb RAACIarticlemhc moleculestymusalloreactivitytolerancegraftImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 477-488 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	mhc molecules tymus alloreactivity tolerance graft Immunologic diseases. Allergy RC581-607
spellingShingle	mhc molecules tymus alloreactivity tolerance graft Immunologic diseases. Allergy RC581-607 D. B. Kazanskii ORIGINS OF ALLOGENEIC RESPONSE
description	Abstract. The MHC molecules are the strongest transplantational antigens determining direct intraction with 95-98% of T cell clones activating in response to allograft. Interaction with MHC molecules is critically important for positive selection of thymocytes and subsequent acquiring the capability to recognize "self" and "foreign". In this light, alloreactivity was recognized as cross-reactivity with foreign MHC that appeared as result of repertoire selection on "self" MHC molecules. The T lymphocyte repertoire is formed in the thymus as a result of random rearrangement of germinal sequences of TCR gene fragments and other processes that bring about the diversity of TCRs. As shown by D. Raulet and co-workers, repertoire of T lymphocytes artificially formed at the absence of selection processes, is inherently capable of reacting with different allelic forms of MHC molecules. In contrast to germinal sequences of TCR fragments, the MHC molecules are characterized by a significant interspecies polymorphism. So, negative and positive selection are aimed at the adaptation of repertoire to the specific MHC-environment of certain individual. The overall goal of adaptation is the elimination of autoreactive clones and sparing a broad spectrum of specificity to potential pathogens. Recent results have shown that positive selection in thymus was result of degenerative recognition of endog- enous MHC/peptide complexes. In contrast, central, telerance to "self" is formed as result of high affinity specific interaction with self MHC/peptide complexes. From this viewpoint the negative selection in the thymus can be considered as a life-long allogenic reaction of repertoire to self MHC molecules; the responses of the mature T cell repertoire to individual antigenic peptides can be considered as cross-reactions of T cells reactive to foreign transplantational antigens. I believe that this interpretation can unveil the origins and biological mean-ingfulness of allogenic reactions.
format	article
author	D. B. Kazanskii
author_facet	D. B. Kazanskii
author_sort	D. B. Kazanskii
title	ORIGINS OF ALLOGENEIC RESPONSE
title_short	ORIGINS OF ALLOGENEIC RESPONSE
title_full	ORIGINS OF ALLOGENEIC RESPONSE
title_fullStr	ORIGINS OF ALLOGENEIC RESPONSE
title_full_unstemmed	ORIGINS OF ALLOGENEIC RESPONSE
title_sort	origins of allogeneic response
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a513d7f4560547e690b9884dfba5aaae
work_keys_str_mv	AT dbkazanskii originsofallogeneicresponse
_version_	1718422496884031488

ORIGINS OF ALLOGENEIC RESPONSE

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