Alzheimer's disease and blood-based biomarkers – potential contexts of use
Martina Zvěřová1,2 1Department of Psychiatry, General University Hospital in Prague, Prague, Czech Republic; 2First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic Abstract: Alzheimer’s disease (AD) is an irreversible, incurable, progressive neurodege...
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Dove Medical Press
2018
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oai:doaj.org-article:a514407a084f4d9b82b3e2f59a195e912021-12-02T00:42:01ZAlzheimer's disease and blood-based biomarkers – potential contexts of use1178-2021https://doaj.org/article/a514407a084f4d9b82b3e2f59a195e912018-07-01T00:00:00Zhttps://www.dovepress.com/alzheimers-disease-and-blood-based-biomarkers-potential-contexts-of-us-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Martina Zvěřová1,2 1Department of Psychiatry, General University Hospital in Prague, Prague, Czech Republic; 2First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic Abstract: Alzheimer’s disease (AD) is an irreversible, incurable, progressive neurodegenerative illness, where dementia symptoms gradually worsen over a number of years. The research of validated biomarkers for AD is essential to improve diagnosis and accelerate the development of new therapies. Biochemical markers including neuroimaging could facilitate diagnosis, predict AD progression from a pre-AD state of mild cognitive impairment, and be used to detect the efficacies of disease-modifying therapies. Established biomarkers of AD from cerebrospinal fluid and neuroimaging are highly accurate, but barriers to clinical implementation exist. The focus on blood-based AD biomarkers has grown exponentially during the past few decades. An ideal diagnostic test for AD should be noninvasive and easily applicable. Clinical cost-effectiveness also needs to be established. Keywords: biomarker, Alzheimer’s disease, neurodegeneration, cerebrospinal fluid, beta amyloid, tau proteinZvěřová MDove Medical PressarticlebiomarkerAlzheimer's diseaseneurodegenerationcerebrospinal fluidbeta amyloidtau proteinNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1877-1882 (2018) |
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DOAJ |
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biomarker Alzheimer's disease neurodegeneration cerebrospinal fluid beta amyloid tau protein Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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biomarker Alzheimer's disease neurodegeneration cerebrospinal fluid beta amyloid tau protein Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zvěřová M Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| description |
Martina Zvěřová1,2 1Department of Psychiatry, General University Hospital in Prague, Prague, Czech Republic; 2First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic Abstract: Alzheimer’s disease (AD) is an irreversible, incurable, progressive neurodegenerative illness, where dementia symptoms gradually worsen over a number of years. The research of validated biomarkers for AD is essential to improve diagnosis and accelerate the development of new therapies. Biochemical markers including neuroimaging could facilitate diagnosis, predict AD progression from a pre-AD state of mild cognitive impairment, and be used to detect the efficacies of disease-modifying therapies. Established biomarkers of AD from cerebrospinal fluid and neuroimaging are highly accurate, but barriers to clinical implementation exist. The focus on blood-based AD biomarkers has grown exponentially during the past few decades. An ideal diagnostic test for AD should be noninvasive and easily applicable. Clinical cost-effectiveness also needs to be established. Keywords: biomarker, Alzheimer’s disease, neurodegeneration, cerebrospinal fluid, beta amyloid, tau protein |
| format |
article |
| author |
Zvěřová M |
| author_facet |
Zvěřová M |
| author_sort |
Zvěřová M |
| title |
Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_short |
Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_full |
Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_fullStr |
Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_full_unstemmed |
Alzheimer's disease and blood-based biomarkers – potential contexts of use |
| title_sort |
alzheimer's disease and blood-based biomarkers – potential contexts of use |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/a514407a084f4d9b82b3e2f59a195e91 |
| work_keys_str_mv |
AT zverovam alzheimer39sdiseaseandbloodbasedbiomarkersndashpotentialcontextsofuse |
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1718403516783919104 |