Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat

Context: Cassia semen (Cs), a seed of Cassia obtusifolia L. (Leguminosae), is a popular functional beverage. Previous studies reported that Cs displayed antioxidant, antifungal and strong liver protective effects. Objective: This study evaluates the hepatoprotective effects of Cs on non-alcoholic fa...

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Autores principales:	Yuanyuan Meng, Yong Liu, Ningning Fang, Yongmin Guo
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	high-fat diet antioxidant low density lipoprotein receptor tnf-α il-6 il-8 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a5159a91905b4722975fed3c76a3ee0d
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spelling	oai:doaj.org-article:a5159a91905b4722975fed3c76a3ee0d2021-11-17T14:21:55ZHepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat1388-02091744-511610.1080/13880209.2019.1568509https://doaj.org/article/a5159a91905b4722975fed3c76a3ee0d2019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1568509https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Cassia semen (Cs), a seed of Cassia obtusifolia L. (Leguminosae), is a popular functional beverage. Previous studies reported that Cs displayed antioxidant, antifungal and strong liver protective effects. Objective: This study evaluates the hepatoprotective effects of Cs on non-alcoholic fatty liver disease (NAFLD). Materials and methods: Seventy-two male Wistar rats raised with high-fat diet (HFD) were randomly allotted into model, metformin (0.2 g/kg) and Cs (0.5, 1, and 2 g/kg)-treated groups. Another 12 rats were raised with normal feed as control group; all the rats were orally administrated with drugs and vehicle for 6 weeks. Alanine transferase (ALT), aspartate transaminase (AST), triglycerides (TG), total cholesterol (TC), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8 and low density lipoprotein receptor (LDL-R) mRNA levels were measured at the end of the experiment. Results: Twelve weeks of HFD administration significantly increased the levels of AST, ALT, TG, TC, TNF-α, IL-6, IL-8 and MDA, decreased SOD (199.42 vs. 137.70 U/mg protein) and GSH (9.76 vs. 4.55 mg/g protein) contents, compared to control group. Cs administration group significantly decreased the elevated biomarkers with the ED50 = 1.2 g/kg for NAFLD rats. Cs treatment also prevents the decreased expression of LDL-R mRNA, and improved the histopathological changes compared to model group. Conclusions: The hepatoprotective effect of Cs on NAFLD may possibly be due to its antioxidant effect. Cs may become a potent hepatoprotective agent in clinical therapy in the future.Yuanyuan MengYong LiuNingning FangYongmin GuoTaylor & Francis Grouparticlehigh-fat dietantioxidantlow density lipoprotein receptortnf-αil-6il-8Therapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 98-104 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	high-fat diet antioxidant low density lipoprotein receptor tnf-α il-6 il-8 Therapeutics. Pharmacology RM1-950
spellingShingle	high-fat diet antioxidant low density lipoprotein receptor tnf-α il-6 il-8 Therapeutics. Pharmacology RM1-950 Yuanyuan Meng Yong Liu Ningning Fang Yongmin Guo Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat
description	Context: Cassia semen (Cs), a seed of Cassia obtusifolia L. (Leguminosae), is a popular functional beverage. Previous studies reported that Cs displayed antioxidant, antifungal and strong liver protective effects. Objective: This study evaluates the hepatoprotective effects of Cs on non-alcoholic fatty liver disease (NAFLD). Materials and methods: Seventy-two male Wistar rats raised with high-fat diet (HFD) were randomly allotted into model, metformin (0.2 g/kg) and Cs (0.5, 1, and 2 g/kg)-treated groups. Another 12 rats were raised with normal feed as control group; all the rats were orally administrated with drugs and vehicle for 6 weeks. Alanine transferase (ALT), aspartate transaminase (AST), triglycerides (TG), total cholesterol (TC), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8 and low density lipoprotein receptor (LDL-R) mRNA levels were measured at the end of the experiment. Results: Twelve weeks of HFD administration significantly increased the levels of AST, ALT, TG, TC, TNF-α, IL-6, IL-8 and MDA, decreased SOD (199.42 vs. 137.70 U/mg protein) and GSH (9.76 vs. 4.55 mg/g protein) contents, compared to control group. Cs administration group significantly decreased the elevated biomarkers with the ED50 = 1.2 g/kg for NAFLD rats. Cs treatment also prevents the decreased expression of LDL-R mRNA, and improved the histopathological changes compared to model group. Conclusions: The hepatoprotective effect of Cs on NAFLD may possibly be due to its antioxidant effect. Cs may become a potent hepatoprotective agent in clinical therapy in the future.
format	article
author	Yuanyuan Meng Yong Liu Ningning Fang Yongmin Guo
author_facet	Yuanyuan Meng Yong Liu Ningning Fang Yongmin Guo
author_sort	Yuanyuan Meng
title	Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat
title_short	Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat
title_full	Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat
title_fullStr	Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat
title_full_unstemmed	Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat
title_sort	hepatoprotective effects of cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/a5159a91905b4722975fed3c76a3ee0d
work_keys_str_mv	AT yuanyuanmeng hepatoprotectiveeffectsofcassiasemenethanolextractonnonalcoholicfattyliverdiseaseinexperimentalrat AT yongliu hepatoprotectiveeffectsofcassiasemenethanolextractonnonalcoholicfattyliverdiseaseinexperimentalrat AT ningningfang hepatoprotectiveeffectsofcassiasemenethanolextractonnonalcoholicfattyliverdiseaseinexperimentalrat AT yongminguo hepatoprotectiveeffectsofcassiasemenethanolextractonnonalcoholicfattyliverdiseaseinexperimentalrat
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Hepatoprotective effects of Cassia semen ethanol extract on non-alcoholic fatty liver disease in experimental rat

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