In vivo biodistribution and behavior of CdTe/ZnS quantum dots

Yan Zhao,1,* Yue Zhang,2,* Gaofeng Qin,1 Jinjun Cheng,1 Wenhao Zeng,2 Shuchen Liu,1 Hui Kong,1 Xueqian Wang,1 Qingguo Wang,1 Huihua Qu3 1School of Basic Medical Sciences, 2School of Chinese Materia Medica, 3Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing, People&...

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Autores principales:	Zhao Y, Zhang Y, Qin G, Cheng J, Zeng W, Liu S, Kong H, Wang X, Wang Q, Qu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Quantum dots lymph nodes fluorescence imaging bio-distribution Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a51632a51f504d1d8e1c880dc0596ae5
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spelling	oai:doaj.org-article:a51632a51f504d1d8e1c880dc0596ae52021-12-02T05:10:42ZIn vivo biodistribution and behavior of CdTe/ZnS quantum dots1178-2013https://doaj.org/article/a51632a51f504d1d8e1c880dc0596ae52017-03-01T00:00:00Zhttps://www.dovepress.com/in-vivo-biodistribution-and-behavior-of-cdtezns-quantum-dots-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yan Zhao,1,* Yue Zhang,2,* Gaofeng Qin,1 Jinjun Cheng,1 Wenhao Zeng,2 Shuchen Liu,1 Hui Kong,1 Xueqian Wang,1 Qingguo Wang,1 Huihua Qu3 1School of Basic Medical Sciences, 2School of Chinese Materia Medica, 3Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: The unique features of quantum dots (QDs) make them desirable fluorescent tags for cell and developmental biology applications that require long-term, multitarget, and highly sensitive imaging. In this work, we imaged fluorescent cadmium telluride/zinc sulfide (CdTe/ZnS) QDs in organs, tissues, and cells, and analyzed the mechanism of their lymphatic uptake and cellular distribution. We observed that the fluorescent CdTe/ZnS QDs were internalized by lymph nodes in four cell lines from different tissue sources. We obtained the fluorescence intensity–QD concentrations curve by quantitative analysis. Our results demonstrate that cells containing QDs can complete mitosis normally and that distribution of QDs was uniform across cell types and involved the vesicular transport system, including the endoplasmic reticulum. This capacity for CdTe/ZnS QD targeting provides insights into the applicability and limitations of fluorescent QDs for imaging biological specimens. Keywords: quantum dots, lymph nodes, fluorescence imaging, biodistributionZhao YZhang YQin GCheng JZeng WLiu SKong HWang XWang QQu HDove Medical PressarticleQuantum dotslymph nodesfluorescence imagingbio-distributionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1927-1939 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Quantum dots lymph nodes fluorescence imaging bio-distribution Medicine (General) R5-920
spellingShingle	Quantum dots lymph nodes fluorescence imaging bio-distribution Medicine (General) R5-920 Zhao Y Zhang Y Qin G Cheng J Zeng W Liu S Kong H Wang X Wang Q Qu H In vivo biodistribution and behavior of CdTe/ZnS quantum dots
description	Yan Zhao,1,* Yue Zhang,2,* Gaofeng Qin,1 Jinjun Cheng,1 Wenhao Zeng,2 Shuchen Liu,1 Hui Kong,1 Xueqian Wang,1 Qingguo Wang,1 Huihua Qu3 1School of Basic Medical Sciences, 2School of Chinese Materia Medica, 3Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: The unique features of quantum dots (QDs) make them desirable fluorescent tags for cell and developmental biology applications that require long-term, multitarget, and highly sensitive imaging. In this work, we imaged fluorescent cadmium telluride/zinc sulfide (CdTe/ZnS) QDs in organs, tissues, and cells, and analyzed the mechanism of their lymphatic uptake and cellular distribution. We observed that the fluorescent CdTe/ZnS QDs were internalized by lymph nodes in four cell lines from different tissue sources. We obtained the fluorescence intensity–QD concentrations curve by quantitative analysis. Our results demonstrate that cells containing QDs can complete mitosis normally and that distribution of QDs was uniform across cell types and involved the vesicular transport system, including the endoplasmic reticulum. This capacity for CdTe/ZnS QD targeting provides insights into the applicability and limitations of fluorescent QDs for imaging biological specimens. Keywords: quantum dots, lymph nodes, fluorescence imaging, biodistribution
format	article
author	Zhao Y Zhang Y Qin G Cheng J Zeng W Liu S Kong H Wang X Wang Q Qu H
author_facet	Zhao Y Zhang Y Qin G Cheng J Zeng W Liu S Kong H Wang X Wang Q Qu H
author_sort	Zhao Y
title	In vivo biodistribution and behavior of CdTe/ZnS quantum dots
title_short	In vivo biodistribution and behavior of CdTe/ZnS quantum dots
title_full	In vivo biodistribution and behavior of CdTe/ZnS quantum dots
title_fullStr	In vivo biodistribution and behavior of CdTe/ZnS quantum dots
title_full_unstemmed	In vivo biodistribution and behavior of CdTe/ZnS quantum dots
title_sort	in vivo biodistribution and behavior of cdte/zns quantum dots
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a51632a51f504d1d8e1c880dc0596ae5
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In vivo biodistribution and behavior of CdTe/ZnS quantum dots

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