The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.

The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.

<h4>Background</h4>In mammals succinic semialdehyde dehydrogenase (SSADH) plays an essential role in the metabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) to succinic acid (SA). Deficiency of SSADH in humans results in elevated levels of GABA and gamma-Hydroxyb...

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Autores principales: Christopher G Langendorf, Trevor L G Key, Gustavo Fenalti, Wan-Ting Kan, Ashley M Buckle, Tom Caradoc-Davies, Kellie L Tuck, Ruby H P Law, James C Whisstock
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a516366723734c67a8727a844c5aaebb
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