Integration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.

Integration is a fundamental working memory operation, requiring the insertion of information from one task into the execution of another concurrent task. Previous neuroimaging studies have suggested the involvement of left anterior prefrontal cortex (L-aPFC) in relation to working memory integratio...

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Autores principales:	Nicola De Pisapia, Marco Sandrini, Todd S Braver, Luigi Cattaneo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a51825be7ac447deae358ea76439507f
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spelling	oai:doaj.org-article:a51825be7ac447deae358ea76439507f2021-11-18T07:07:42ZIntegration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.1932-620310.1371/journal.pone.0043731https://doaj.org/article/a51825be7ac447deae358ea76439507f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22937085/?tool=EBIhttps://doaj.org/toc/1932-6203Integration is a fundamental working memory operation, requiring the insertion of information from one task into the execution of another concurrent task. Previous neuroimaging studies have suggested the involvement of left anterior prefrontal cortex (L-aPFC) in relation to working memory integration demands, increasing during presentation of information to be integrated (loading), throughout its maintenance during a secondary task, up to the integration step, and then decreasing afterward (unloading). Here we used short bursts of 5 Hz repetitive Transcranic Magnetic Stimulation (rTMS) to modulate L-aPFC activity and to assess its causal role in integration. During experimental blocks, rTMS was applied (N = 10) over L-aPFC or vertex (control site) at different time-points of a task involving integration of a preloaded digit into a sequence of arithmetical steps, and contrasted with a closely matched task without integration demand (segregation). When rTMS was applied during the loading phase, reaction times during secondary task were faster, without significant changes in error rates. RTMS instead worsened performance when applied during information unloading. In contrast, no effects were observed when rTMS was applied during the other phases of integration, or during the segregation condition. These results confirm the hypothesis that L-aPFC is causally and selectively involved in the integration of information in working memory. They additionally suggest that pre-integration loading and post-integration unloading of information involving this area may be active and resource-consuming processes.Nicola De PisapiaMarco SandriniTodd S BraverLuigi CattaneoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43731 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicola De Pisapia Marco Sandrini Todd S Braver Luigi Cattaneo Integration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.
description	Integration is a fundamental working memory operation, requiring the insertion of information from one task into the execution of another concurrent task. Previous neuroimaging studies have suggested the involvement of left anterior prefrontal cortex (L-aPFC) in relation to working memory integration demands, increasing during presentation of information to be integrated (loading), throughout its maintenance during a secondary task, up to the integration step, and then decreasing afterward (unloading). Here we used short bursts of 5 Hz repetitive Transcranic Magnetic Stimulation (rTMS) to modulate L-aPFC activity and to assess its causal role in integration. During experimental blocks, rTMS was applied (N = 10) over L-aPFC or vertex (control site) at different time-points of a task involving integration of a preloaded digit into a sequence of arithmetical steps, and contrasted with a closely matched task without integration demand (segregation). When rTMS was applied during the loading phase, reaction times during secondary task were faster, without significant changes in error rates. RTMS instead worsened performance when applied during information unloading. In contrast, no effects were observed when rTMS was applied during the other phases of integration, or during the segregation condition. These results confirm the hypothesis that L-aPFC is causally and selectively involved in the integration of information in working memory. They additionally suggest that pre-integration loading and post-integration unloading of information involving this area may be active and resource-consuming processes.
format	article
author	Nicola De Pisapia Marco Sandrini Todd S Braver Luigi Cattaneo
author_facet	Nicola De Pisapia Marco Sandrini Todd S Braver Luigi Cattaneo
author_sort	Nicola De Pisapia
title	Integration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.
title_short	Integration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.
title_full	Integration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.
title_fullStr	Integration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.
title_full_unstemmed	Integration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.
title_sort	integration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a51825be7ac447deae358ea76439507f
work_keys_str_mv	AT nicoladepisapia integrationinworkingmemoryamagneticstimulationstudyontheroleofleftanteriorprefrontalcortex AT marcosandrini integrationinworkingmemoryamagneticstimulationstudyontheroleofleftanteriorprefrontalcortex AT toddsbraver integrationinworkingmemoryamagneticstimulationstudyontheroleofleftanteriorprefrontalcortex AT luigicattaneo integrationinworkingmemoryamagneticstimulationstudyontheroleofleftanteriorprefrontalcortex
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Integration in working memory: a magnetic stimulation study on the role of left anterior prefrontal cortex.

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