The PINK1—Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells

The PINK1—Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells

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Mutations in the PINK1 and PRKN genes are the most common cause of early-onset familial Parkinson disease. These genes code for the PINK1 and Parkin proteins, respectively, which are involved in the degradation of dysfunctional mitochondria through mitophagy. An early step in PINK1 –Parkin mediated...

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Autores principales: Aaron V. Bradshaw, Philip Campbell, Anthony H. V. Schapira, Huw R. Morris, Jan-Willem Taanman
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a5194ae77b30451d96bafab773aefae9
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