A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity

A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity

Many cancers fuel their rapid growth by replacing glucokinase with its higher affinity isoenzyme, hexokinase 2 (HK2), making HK2 an attractive drug target. In this study, Perrin-Cocon and Vidalain et al. use CRISPR/Cas-9 gene editing to reverse this enzymatic switch in human liver cancer cells, and...

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Autores principales: Laure Perrin-Cocon, Pierre-Olivier Vidalain, Clémence Jacquemin, Anne Aublin-Gex, Keedrian Olmstead, Baptiste Panthu, Gilles Jeans Philippe Rautureau, Patrice André, Piotr Nyczka, Marc-Thorsten Hütt, Nivea Amoedo, Rodrigue Rossignol, Fabian Volker Filipp, Vincent Lotteau, Olivier Diaz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/a519b0af2fba49868394944910f843d0
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spelling oai:doaj.org-article:a519b0af2fba49868394944910f843d02021-12-02T14:03:55ZA hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity10.1038/s42003-021-01749-32399-3642https://doaj.org/article/a519b0af2fba49868394944910f843d02021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01749-3https://doaj.org/toc/2399-3642Many cancers fuel their rapid growth by replacing glucokinase with its higher affinity isoenzyme, hexokinase 2 (HK2), making HK2 an attractive drug target. In this study, Perrin-Cocon and Vidalain et al. use CRISPR/Cas-9 gene editing to reverse this enzymatic switch in human liver cancer cells, and find this restores innate immune function as well as reversing cancer-associated metabolic reprogramming.Laure Perrin-CoconPierre-Olivier VidalainClémence JacqueminAnne Aublin-GexKeedrian OlmsteadBaptiste PanthuGilles Jeans Philippe RautureauPatrice AndréPiotr NyczkaMarc-Thorsten HüttNivea AmoedoRodrigue RossignolFabian Volker FilippVincent LotteauOlivier DiazNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Laure Perrin-Cocon
Pierre-Olivier Vidalain
Clémence Jacquemin
Anne Aublin-Gex
Keedrian Olmstead
Baptiste Panthu
Gilles Jeans Philippe Rautureau
Patrice André
Piotr Nyczka
Marc-Thorsten Hütt
Nivea Amoedo
Rodrigue Rossignol
Fabian Volker Filipp
Vincent Lotteau
Olivier Diaz
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
description Many cancers fuel their rapid growth by replacing glucokinase with its higher affinity isoenzyme, hexokinase 2 (HK2), making HK2 an attractive drug target. In this study, Perrin-Cocon and Vidalain et al. use CRISPR/Cas-9 gene editing to reverse this enzymatic switch in human liver cancer cells, and find this restores innate immune function as well as reversing cancer-associated metabolic reprogramming.
format article
author Laure Perrin-Cocon
Pierre-Olivier Vidalain
Clémence Jacquemin
Anne Aublin-Gex
Keedrian Olmstead
Baptiste Panthu
Gilles Jeans Philippe Rautureau
Patrice André
Piotr Nyczka
Marc-Thorsten Hütt
Nivea Amoedo
Rodrigue Rossignol
Fabian Volker Filipp
Vincent Lotteau
Olivier Diaz
author_facet Laure Perrin-Cocon
Pierre-Olivier Vidalain
Clémence Jacquemin
Anne Aublin-Gex
Keedrian Olmstead
Baptiste Panthu
Gilles Jeans Philippe Rautureau
Patrice André
Piotr Nyczka
Marc-Thorsten Hütt
Nivea Amoedo
Rodrigue Rossignol
Fabian Volker Filipp
Vincent Lotteau
Olivier Diaz
author_sort Laure Perrin-Cocon
title A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
title_short A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
title_full A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
title_fullStr A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
title_full_unstemmed A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
title_sort hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a519b0af2fba49868394944910f843d0
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