Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery

Abstract Tinnitus is attributed to partial sensory deafferentation resulting in a central maladaptive neuroplasticity. Unfortunately, the agent of deafferentation is usually unknown or irreversible. In patients with unilateral vestibular schwannoma (VS), however, the auditory nerve is affected by a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Leonidas Trakolis, Benjamin Bender, Florian H. Ebner, Ulrike Ernemann, Marcos Tatagiba, Georgios Naros
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a51ccc95dad047edb9966fb7c935e5f7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a51ccc95dad047edb9966fb7c935e5f7
record_format	dspace
spelling	oai:doaj.org-article:a51ccc95dad047edb9966fb7c935e5f72021-12-02T15:51:12ZCortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery10.1038/s41598-021-87915-32045-2322https://doaj.org/article/a51ccc95dad047edb9966fb7c935e5f72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87915-3https://doaj.org/toc/2045-2322Abstract Tinnitus is attributed to partial sensory deafferentation resulting in a central maladaptive neuroplasticity. Unfortunately, the agent of deafferentation is usually unknown or irreversible. In patients with unilateral vestibular schwannoma (VS), however, the auditory nerve is affected by a benign tumor. Hence, removal of the tumor can cease the tinnitus. In turn, sustaining complaints after surgery indicate cortical neuroplasticity. The present study is a cross sectional study which aims to track cortical structural changes by surface-based morphometry in 46 VS patients with sustained (i.e. centralized) or ceased (i.e. peripheral) tinnitus after surgery. A volumetric analysis of cortical and subcortical gray matter (GM) anatomy was performed on preoperative high-resolution MRI and related to the presence of hearing impairment, pre- and/or postoperative tinnitus. Patients with sustained (i.e. chronic) tinnitus showed an increased GM volume of the bilateral caudate nucleus, the contralateral superior colliculus, the middle frontal and middle temporal gyrus, the fusiform gyrus as well as the ipsilateral pars orbitalis when compared to those patients in whom tinnitus ceased postoperatively. Chronic tinnitus in VS patients is associated with characteristic structural changes in frontal, temporal and subcortical areas. Notably, a significant GM change of the caudate nucleus was detected providing further support for the striatal gaiting model of tinnitus.Leonidas TrakolisBenjamin BenderFlorian H. EbnerUlrike ErnemannMarcos TatagibaGeorgios NarosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leonidas Trakolis Benjamin Bender Florian H. Ebner Ulrike Ernemann Marcos Tatagiba Georgios Naros Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery
description	Abstract Tinnitus is attributed to partial sensory deafferentation resulting in a central maladaptive neuroplasticity. Unfortunately, the agent of deafferentation is usually unknown or irreversible. In patients with unilateral vestibular schwannoma (VS), however, the auditory nerve is affected by a benign tumor. Hence, removal of the tumor can cease the tinnitus. In turn, sustaining complaints after surgery indicate cortical neuroplasticity. The present study is a cross sectional study which aims to track cortical structural changes by surface-based morphometry in 46 VS patients with sustained (i.e. centralized) or ceased (i.e. peripheral) tinnitus after surgery. A volumetric analysis of cortical and subcortical gray matter (GM) anatomy was performed on preoperative high-resolution MRI and related to the presence of hearing impairment, pre- and/or postoperative tinnitus. Patients with sustained (i.e. chronic) tinnitus showed an increased GM volume of the bilateral caudate nucleus, the contralateral superior colliculus, the middle frontal and middle temporal gyrus, the fusiform gyrus as well as the ipsilateral pars orbitalis when compared to those patients in whom tinnitus ceased postoperatively. Chronic tinnitus in VS patients is associated with characteristic structural changes in frontal, temporal and subcortical areas. Notably, a significant GM change of the caudate nucleus was detected providing further support for the striatal gaiting model of tinnitus.
format	article
author	Leonidas Trakolis Benjamin Bender Florian H. Ebner Ulrike Ernemann Marcos Tatagiba Georgios Naros
author_facet	Leonidas Trakolis Benjamin Bender Florian H. Ebner Ulrike Ernemann Marcos Tatagiba Georgios Naros
author_sort	Leonidas Trakolis
title	Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery
title_short	Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery
title_full	Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery
title_fullStr	Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery
title_full_unstemmed	Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery
title_sort	cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a51ccc95dad047edb9966fb7c935e5f7
work_keys_str_mv	AT leonidastrakolis corticalandsubcorticalgraymatterchangesinpatientswithchronictinnitussustainingaftervestibularschwannomasurgery AT benjaminbender corticalandsubcorticalgraymatterchangesinpatientswithchronictinnitussustainingaftervestibularschwannomasurgery AT florianhebner corticalandsubcorticalgraymatterchangesinpatientswithchronictinnitussustainingaftervestibularschwannomasurgery AT ulrikeernemann corticalandsubcorticalgraymatterchangesinpatientswithchronictinnitussustainingaftervestibularschwannomasurgery AT marcostatagiba corticalandsubcorticalgraymatterchangesinpatientswithchronictinnitussustainingaftervestibularschwannomasurgery AT georgiosnaros corticalandsubcorticalgraymatterchangesinpatientswithchronictinnitussustainingaftervestibularschwannomasurgery
_version_	1718385651297026048

Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery

Ejemplares similares