Elevated Long Term Resting Heart Rate Variation is Associated with Increased Risk of All-cause Mortality in Northern China
Abstract Elevated resting heart rate (RHR) predicts all-cause death. However, the relationship between RHR variation over years and mortality are still unknown. We aimed to analyze the association between RHR variation and all-cause mortality in the general population without cardiovascular diseases...
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2017
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oai:doaj.org-article:a51db438d27943bb937bf10d5d0c0a802021-12-02T12:32:55ZElevated Long Term Resting Heart Rate Variation is Associated with Increased Risk of All-cause Mortality in Northern China10.1038/s41598-017-07309-22045-2322https://doaj.org/article/a51db438d27943bb937bf10d5d0c0a802017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07309-2https://doaj.org/toc/2045-2322Abstract Elevated resting heart rate (RHR) predicts all-cause death. However, the relationship between RHR variation over years and mortality are still unknown. We aimed to analyze the association between RHR variation and all-cause mortality in the general population without cardiovascular diseases. A total of 46,873 subjects were included from the Kailuan Study (2006–2011). RHR readings were taken during three separate examinations and the RHR variation was defined using the standard deviation (RHR-SD) and the coefficient of variation. Participants were divided into four groups according to the quartiles of RHR-SD. All subjects were followed for a median of 49.4 months from the date of the 3rd examination to December 31, 2014. Up until the follow-up examinations, 973 (2.08%) participants had died. In a multivariate analysis, adjusting for variables potentially associated with death, the highest quartile of RHR-SD remained an independent predictor of all-cause mortality (Hazards ratio = 1.43, 95% confidence interval 1.18–1.74, P < 0.001). These findings suggest that an elevated long-term RHR variation is an independent risk marker for all-cause mortality in the general population without known cardiovascular diseases.Binhao WangHuihua LiXu HanYiheng YangYue ChenWenyu LiXiaolei YangAijun XingYanxiu WangTesfaldet Habtemariam HidruShouling WuYunlong XiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) |
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Medicine R Science Q Binhao Wang Huihua Li Xu Han Yiheng Yang Yue Chen Wenyu Li Xiaolei Yang Aijun Xing Yanxiu Wang Tesfaldet Habtemariam Hidru Shouling Wu Yunlong Xia Elevated Long Term Resting Heart Rate Variation is Associated with Increased Risk of All-cause Mortality in Northern China |
| description |
Abstract Elevated resting heart rate (RHR) predicts all-cause death. However, the relationship between RHR variation over years and mortality are still unknown. We aimed to analyze the association between RHR variation and all-cause mortality in the general population without cardiovascular diseases. A total of 46,873 subjects were included from the Kailuan Study (2006–2011). RHR readings were taken during three separate examinations and the RHR variation was defined using the standard deviation (RHR-SD) and the coefficient of variation. Participants were divided into four groups according to the quartiles of RHR-SD. All subjects were followed for a median of 49.4 months from the date of the 3rd examination to December 31, 2014. Up until the follow-up examinations, 973 (2.08%) participants had died. In a multivariate analysis, adjusting for variables potentially associated with death, the highest quartile of RHR-SD remained an independent predictor of all-cause mortality (Hazards ratio = 1.43, 95% confidence interval 1.18–1.74, P < 0.001). These findings suggest that an elevated long-term RHR variation is an independent risk marker for all-cause mortality in the general population without known cardiovascular diseases. |
| format |
article |
| author |
Binhao Wang Huihua Li Xu Han Yiheng Yang Yue Chen Wenyu Li Xiaolei Yang Aijun Xing Yanxiu Wang Tesfaldet Habtemariam Hidru Shouling Wu Yunlong Xia |
| author_facet |
Binhao Wang Huihua Li Xu Han Yiheng Yang Yue Chen Wenyu Li Xiaolei Yang Aijun Xing Yanxiu Wang Tesfaldet Habtemariam Hidru Shouling Wu Yunlong Xia |
| author_sort |
Binhao Wang |
| title |
Elevated Long Term Resting Heart Rate Variation is Associated with Increased Risk of All-cause Mortality in Northern China |
| title_short |
Elevated Long Term Resting Heart Rate Variation is Associated with Increased Risk of All-cause Mortality in Northern China |
| title_full |
Elevated Long Term Resting Heart Rate Variation is Associated with Increased Risk of All-cause Mortality in Northern China |
| title_fullStr |
Elevated Long Term Resting Heart Rate Variation is Associated with Increased Risk of All-cause Mortality in Northern China |
| title_full_unstemmed |
Elevated Long Term Resting Heart Rate Variation is Associated with Increased Risk of All-cause Mortality in Northern China |
| title_sort |
elevated long term resting heart rate variation is associated with increased risk of all-cause mortality in northern china |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a51db438d27943bb937bf10d5d0c0a80 |
| work_keys_str_mv |
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1718393937721294848 |