Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment

Shwu-Jiuan Sheu,1,2 Ying-Yen Lee,1 Yu-Harn Horng,1 Huey-Shyan Lin,3 Wei-Yu Lai,1 Chui-Lien Tsen1 1Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 3Department of Heal...

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Autores principales:	Sheu SJ, Lee YY, Horng YH, Lin HS, Lai WY, Tsen CL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	diabetic macular edema Optical Coherence Tomography (OCT) subretinal fluid (SRF) vascular endothelial growth factor (VEGF) Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a51db4b9a62d48acb71d57bba277532a
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spelling	oai:doaj.org-article:a51db4b9a62d48acb71d57bba277532a2021-12-02T08:06:44ZCharacteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment1177-5483https://doaj.org/article/a51db4b9a62d48acb71d57bba277532a2018-09-01T00:00:00Zhttps://www.dovepress.com/characteristics-of-diabetic-macular-edema-on-optical-coherence-tomogra-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Shwu-Jiuan Sheu,1,2 Ying-Yen Lee,1 Yu-Harn Horng,1 Huey-Shyan Lin,3 Wei-Yu Lai,1 Chui-Lien Tsen1 1Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 3Department of Health-Business Administration, Fooyin University, Kaohsiung, Taiwan Purpose: To investigate optical coherence tomography (OCT) characteristics in diabetic macular edema (DME) over time and after treatment. Patients and methods: OCT morphological features in DME eyes treated with ranibizumab with at least 1 year of follow-up were retrospectively analyzed. Results: Thirty-five eyes were included. From baseline to Month 12, mean visual gain was 7.2±13.6 letters and mean central retinal thickness reduction was 61.9±121.8 µm. Fovea-involving ellipsoid zone (EZ) disruption was significantly associated with final vision of <70 letters. Subretinal fluid at baseline was present only in eyes naïve to previous intravitreal pharmacotherapy and was related to better visual gain and fewer injections. Treatment-naïve eyes had shorter DME duration and less EZ damage. Conclusion: DME characteristics on OCT may change over time or after treatment. Subretinal fluid may be associated with earlier change and less EZ damage in DME. Keywords: diabetic macular edema, optical coherence tomography, OCT, subretinal fluid, SRF, vascular endothelial growth factor, VEGFSheu SJLee YYHorng YHLin HSLai WYTsen CLDove Medical Pressarticlediabetic macular edemaOptical Coherence Tomography (OCT)subretinal fluid (SRF)vascular endothelial growth factor (VEGF)OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1887-1893 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic macular edema Optical Coherence Tomography (OCT) subretinal fluid (SRF) vascular endothelial growth factor (VEGF) Ophthalmology RE1-994
spellingShingle	diabetic macular edema Optical Coherence Tomography (OCT) subretinal fluid (SRF) vascular endothelial growth factor (VEGF) Ophthalmology RE1-994 Sheu SJ Lee YY Horng YH Lin HS Lai WY Tsen CL Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment
description	Shwu-Jiuan Sheu,1,2 Ying-Yen Lee,1 Yu-Harn Horng,1 Huey-Shyan Lin,3 Wei-Yu Lai,1 Chui-Lien Tsen1 1Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 3Department of Health-Business Administration, Fooyin University, Kaohsiung, Taiwan Purpose: To investigate optical coherence tomography (OCT) characteristics in diabetic macular edema (DME) over time and after treatment. Patients and methods: OCT morphological features in DME eyes treated with ranibizumab with at least 1 year of follow-up were retrospectively analyzed. Results: Thirty-five eyes were included. From baseline to Month 12, mean visual gain was 7.2±13.6 letters and mean central retinal thickness reduction was 61.9±121.8 µm. Fovea-involving ellipsoid zone (EZ) disruption was significantly associated with final vision of <70 letters. Subretinal fluid at baseline was present only in eyes naïve to previous intravitreal pharmacotherapy and was related to better visual gain and fewer injections. Treatment-naïve eyes had shorter DME duration and less EZ damage. Conclusion: DME characteristics on OCT may change over time or after treatment. Subretinal fluid may be associated with earlier change and less EZ damage in DME. Keywords: diabetic macular edema, optical coherence tomography, OCT, subretinal fluid, SRF, vascular endothelial growth factor, VEGF
format	article
author	Sheu SJ Lee YY Horng YH Lin HS Lai WY Tsen CL
author_facet	Sheu SJ Lee YY Horng YH Lin HS Lai WY Tsen CL
author_sort	Sheu SJ
title	Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment
title_short	Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment
title_full	Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment
title_fullStr	Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment
title_full_unstemmed	Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment
title_sort	characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/a51db4b9a62d48acb71d57bba277532a
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_version_	1718398677428469760

Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment

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