Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

The spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent splicing factory assembling the TTN locus with other R...

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Autores principales:	Alessandro Bertero, Paul A. Fields, Vijay Ramani, Giancarlo Bonora, Galip G. Yardimci, Hans Reinecke, Lil Pabon, William S. Noble, Jay Shendure, Charles E. Murry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a51e8f8741a942b2bf348aa7a7f3475f
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spelling	oai:doaj.org-article:a51e8f8741a942b2bf348aa7a7f3475f2021-12-02T14:39:00ZDynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory10.1038/s41467-019-09483-52041-1723https://doaj.org/article/a51e8f8741a942b2bf348aa7a7f3475f2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09483-5https://doaj.org/toc/2041-1723The spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent splicing factory assembling the TTN locus with other RBM20 targets.Alessandro BerteroPaul A. FieldsVijay RamaniGiancarlo BonoraGalip G. YardimciHans ReineckeLil PabonWilliam S. NobleJay ShendureCharles E. MurryNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Bertero Paul A. Fields Vijay Ramani Giancarlo Bonora Galip G. Yardimci Hans Reinecke Lil Pabon William S. Noble Jay Shendure Charles E. Murry Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
description	The spatial organization of the genome plays an important but unclearly defined role in gene regulation. Here, the authors integrate Hi-C, RNA-seq and ATAC-seq data to map cardiogenesis from pluripotent stem cells and describe an RBM20-dependent splicing factory assembling the TTN locus with other RBM20 targets.
format	article
author	Alessandro Bertero Paul A. Fields Vijay Ramani Giancarlo Bonora Galip G. Yardimci Hans Reinecke Lil Pabon William S. Noble Jay Shendure Charles E. Murry
author_facet	Alessandro Bertero Paul A. Fields Vijay Ramani Giancarlo Bonora Galip G. Yardimci Hans Reinecke Lil Pabon William S. Noble Jay Shendure Charles E. Murry
author_sort	Alessandro Bertero
title	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_short	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_full	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_fullStr	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_full_unstemmed	Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
title_sort	dynamics of genome reorganization during human cardiogenesis reveal an rbm20-dependent splicing factory
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a51e8f8741a942b2bf348aa7a7f3475f
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Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory

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